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Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase (Lck)

The membrane-bound lymphocyte-specific protein-tyrosine kinase (Lck) triggers T cell antigen receptor signalling to initiate adaptive immune responses. Despite many structure–function studies, the mode of action of Lck and the potential role of plasma membrane lipids in regulating Lck’s activity rem...

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Detalles Bibliográficos
Autores principales:	Prakaash, Dheeraj, Fagnen, Charline, Cook, Graham P., Acuto, Oreste, Kalli, Antreas C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729596/ https://www.ncbi.nlm.nih.gov/pubmed/36476673 http://dx.doi.org/10.1038/s41598-022-25603-6

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