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Discovery and structural optimization of 3-O-β-Chacotriosyl betulonic acid saponins as potent fusion inhibitors of Omicron virus infections

The recent global Omicron epidemics underscore the great need for the development of small molecule therapeutics with appropriate mechanisms. The trimeric spike protein (S) of SARS-CoV-2 plays a pivotal role in mediating viral entry into host cells. We continued our efforts to develop small-molecule...

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Detalles Bibliográficos
Autores principales:	Liu, Mingjian, Wang, Jinshen, Wan, Xin, Li, Baixi, Guan, Mingming, Ning, Xiaoyun, Hu, Xiaojie, Li, Sumei, Liu, Shuwen, Song, Gaopeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729598/ https://www.ncbi.nlm.nih.gov/pubmed/36508939 http://dx.doi.org/10.1016/j.bioorg.2022.106316

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