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Direct thrombin inhibitors as alternatives to heparin to preserve lung growth and function in a murine model of compensatory lung growth

Infants with congenital diaphragmatic hernia (CDH) may require cardiopulmonary bypass and systemic anticoagulation. Expeditious lung growth while on bypass is essential for survival. Previously, we demonstrated that heparin impairs lung growth and function in a murine model of compensatory lung grow...

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Detalles Bibliográficos
Autores principales: Tsikis, Savas T., Hirsch, Thomas I., Fligor, Scott C., Pan, Amy, Joiner, Malachi M., Devietro, Angela, Mitchell, Paul D., Kishikawa, Hiroko, Gura, Kathleen M., Puder, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729628/
https://www.ncbi.nlm.nih.gov/pubmed/36477689
http://dx.doi.org/10.1038/s41598-022-25773-3