Cargando…
Characteristics of unvaccinated and vaccinated critically ill COVID-19 patients in calabria region (Italy): A retrospective study
INTRODUCTION: After the rapid surge of a novel coronavirus (SARS-CoV-2) in 2020 anti-SARS-CoV-2 vaccines have been developed to prevent the development of critical forms of COVID-19 leading to Intensive Care Unit (ICU) admission. The possibility of ICU admission after the first-cycle vaccination has...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729689/ https://www.ncbi.nlm.nih.gov/pubmed/36507545 http://dx.doi.org/10.3389/fmed.2022.1042411 |
_version_ | 1784845523221479424 |
---|---|
author | Bruni, Andrea Longhini, Federico Macheda, Sebastiano Biamonte, Eugenio Pasqua, Pino Neri, Giuseppe Guzzo, Maria Laura Garofalo, Eugenio |
author_facet | Bruni, Andrea Longhini, Federico Macheda, Sebastiano Biamonte, Eugenio Pasqua, Pino Neri, Giuseppe Guzzo, Maria Laura Garofalo, Eugenio |
author_sort | Bruni, Andrea |
collection | PubMed |
description | INTRODUCTION: After the rapid surge of a novel coronavirus (SARS-CoV-2) in 2020 anti-SARS-CoV-2 vaccines have been developed to prevent the development of critical forms of COVID-19 leading to Intensive Care Unit (ICU) admission. The possibility of ICU admission after the first-cycle vaccination has been already reported; however, no data have been published regarding vaccinated patients with a “booster” dose. This retrospective study describes the characteristics of critically ill patients after the implementation of the regional “booster” dose vaccination program in a southern region of Italy. MATERIALS AND METHODS: We screened all medical records of critically ill COVID-19 patients in the period between January to April 2022. We collected the demographic characteristics, the presence of comorbidities, the vaccination status, the clinical course (arterial blood gases and type of respiratory support) and outcomes (rate of tracheostomy, ICU length of stay and mortality). RESULTS: A total of 272 patients were admitted to ICUs during the study period. 161 patients were unvaccinated, whereas 111 were vaccinated with the complete first-cycle or “booster” dose. The type of respiratory support was similar between groups. Vaccinated patients were characterized by a better oxygenation throughout the whole ICU length of stay. Fourteen unvaccinated and 3 vaccinated patients required tracheostomy (p = 0.045). ICU length of stay was 12.2 (± 7.3) days in unvaccinated patients and 10.4 (± 6.7) days in vaccinated patients (p = 0.036). ICU mortalities were 38.5 and 24.3% in unvaccinated and vaccinated patients, respectively (p = 0.014). CONCLUSION: Vaccinated patients have better clinical course and outcomes as compared to the unvaccinated population. |
format | Online Article Text |
id | pubmed-9729689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97296892022-12-09 Characteristics of unvaccinated and vaccinated critically ill COVID-19 patients in calabria region (Italy): A retrospective study Bruni, Andrea Longhini, Federico Macheda, Sebastiano Biamonte, Eugenio Pasqua, Pino Neri, Giuseppe Guzzo, Maria Laura Garofalo, Eugenio Front Med (Lausanne) Medicine INTRODUCTION: After the rapid surge of a novel coronavirus (SARS-CoV-2) in 2020 anti-SARS-CoV-2 vaccines have been developed to prevent the development of critical forms of COVID-19 leading to Intensive Care Unit (ICU) admission. The possibility of ICU admission after the first-cycle vaccination has been already reported; however, no data have been published regarding vaccinated patients with a “booster” dose. This retrospective study describes the characteristics of critically ill patients after the implementation of the regional “booster” dose vaccination program in a southern region of Italy. MATERIALS AND METHODS: We screened all medical records of critically ill COVID-19 patients in the period between January to April 2022. We collected the demographic characteristics, the presence of comorbidities, the vaccination status, the clinical course (arterial blood gases and type of respiratory support) and outcomes (rate of tracheostomy, ICU length of stay and mortality). RESULTS: A total of 272 patients were admitted to ICUs during the study period. 161 patients were unvaccinated, whereas 111 were vaccinated with the complete first-cycle or “booster” dose. The type of respiratory support was similar between groups. Vaccinated patients were characterized by a better oxygenation throughout the whole ICU length of stay. Fourteen unvaccinated and 3 vaccinated patients required tracheostomy (p = 0.045). ICU length of stay was 12.2 (± 7.3) days in unvaccinated patients and 10.4 (± 6.7) days in vaccinated patients (p = 0.036). ICU mortalities were 38.5 and 24.3% in unvaccinated and vaccinated patients, respectively (p = 0.014). CONCLUSION: Vaccinated patients have better clinical course and outcomes as compared to the unvaccinated population. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9729689/ /pubmed/36507545 http://dx.doi.org/10.3389/fmed.2022.1042411 Text en Copyright © 2022 Bruni, Longhini, Macheda, Biamonte, Pasqua, Neri, Guzzo, Garofalo and Calabria COVID-ICU Network authors. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Bruni, Andrea Longhini, Federico Macheda, Sebastiano Biamonte, Eugenio Pasqua, Pino Neri, Giuseppe Guzzo, Maria Laura Garofalo, Eugenio Characteristics of unvaccinated and vaccinated critically ill COVID-19 patients in calabria region (Italy): A retrospective study |
title | Characteristics of unvaccinated and vaccinated critically ill COVID-19 patients in calabria region (Italy): A retrospective study |
title_full | Characteristics of unvaccinated and vaccinated critically ill COVID-19 patients in calabria region (Italy): A retrospective study |
title_fullStr | Characteristics of unvaccinated and vaccinated critically ill COVID-19 patients in calabria region (Italy): A retrospective study |
title_full_unstemmed | Characteristics of unvaccinated and vaccinated critically ill COVID-19 patients in calabria region (Italy): A retrospective study |
title_short | Characteristics of unvaccinated and vaccinated critically ill COVID-19 patients in calabria region (Italy): A retrospective study |
title_sort | characteristics of unvaccinated and vaccinated critically ill covid-19 patients in calabria region (italy): a retrospective study |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729689/ https://www.ncbi.nlm.nih.gov/pubmed/36507545 http://dx.doi.org/10.3389/fmed.2022.1042411 |
work_keys_str_mv | AT bruniandrea characteristicsofunvaccinatedandvaccinatedcriticallyillcovid19patientsincalabriaregionitalyaretrospectivestudy AT longhinifederico characteristicsofunvaccinatedandvaccinatedcriticallyillcovid19patientsincalabriaregionitalyaretrospectivestudy AT machedasebastiano characteristicsofunvaccinatedandvaccinatedcriticallyillcovid19patientsincalabriaregionitalyaretrospectivestudy AT biamonteeugenio characteristicsofunvaccinatedandvaccinatedcriticallyillcovid19patientsincalabriaregionitalyaretrospectivestudy AT pasquapino characteristicsofunvaccinatedandvaccinatedcriticallyillcovid19patientsincalabriaregionitalyaretrospectivestudy AT nerigiuseppe characteristicsofunvaccinatedandvaccinatedcriticallyillcovid19patientsincalabriaregionitalyaretrospectivestudy AT guzzomarialaura characteristicsofunvaccinatedandvaccinatedcriticallyillcovid19patientsincalabriaregionitalyaretrospectivestudy AT garofaloeugenio characteristicsofunvaccinatedandvaccinatedcriticallyillcovid19patientsincalabriaregionitalyaretrospectivestudy AT characteristicsofunvaccinatedandvaccinatedcriticallyillcovid19patientsincalabriaregionitalyaretrospectivestudy |