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Enrichment of T-cell proliferation and memory gene signatures of CD79A/CD40 costimulatory domain potentiates CD19CAR-T cell functions

CD19 chimeric antigen receptor (CAR) T-cells have demonstrated remarkable outcomes in B-cell malignancies. Recently, the novel CD19CAR-T cells incorporated with B-cell costimulatory molecules of CD79A/CD40 demonstrated superior antitumor activity in the B-cell lymphoma model compared with CD28 or 4-...

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Detalles Bibliográficos
Autores principales:	Ung, Socheatraksmey, Choochuen, Pongsakorn, Khopanlert, Wannakorn, Maneechai, Kajornkiat, Sangkhathat, Surasak, Terakura, Seitaro, Julamanee, Jakrawadee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729744/ https://www.ncbi.nlm.nih.gov/pubmed/36505428 http://dx.doi.org/10.3389/fimmu.2022.1064339

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