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Serum triglycerides level is independently associated with renal outcomes in patients with non-dialysis chronic kidney disease: Results from KNOW-CKD study

To investigate whether high serum triglycerides (TG) level is associated with adverse renal outcomes in patients with non-dialysis chronic kidney disease (CKD), a total of 2,158 subjects from a prospective cohort study (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease) were di...

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Autores principales: Suh, Sang Heon, Oh, Tae Ryom, Choi, Hong Sang, Kim, Chang Seong, Bae, Eun Hui, Oh, Kook-Hwan, Han, Seung Hyeok, Ma, Seong Kwon, Kim, Soo Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729769/
https://www.ncbi.nlm.nih.gov/pubmed/36505239
http://dx.doi.org/10.3389/fnut.2022.1037618
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author Suh, Sang Heon
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Bae, Eun Hui
Oh, Kook-Hwan
Han, Seung Hyeok
Ma, Seong Kwon
Kim, Soo Wan
author_facet Suh, Sang Heon
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Bae, Eun Hui
Oh, Kook-Hwan
Han, Seung Hyeok
Ma, Seong Kwon
Kim, Soo Wan
author_sort Suh, Sang Heon
collection PubMed
description To investigate whether high serum triglycerides (TG) level is associated with adverse renal outcomes in patients with non-dialysis chronic kidney disease (CKD), a total of 2,158 subjects from a prospective cohort study (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease) were divided into the quartile by serum TG level. The primary outcomes were composite renal events, which is defined as a composite of decline of kidney function (the first occurrence of > 50% decline of estimated glomerular filtration rate or doubling of serum creatinine from the baseline) or onset of end-stage renal disease (initiation of dialysis or kidney transplantation). During the median follow-up of 6.940 years, the cumulative incidence of composite renal event was significantly differed by serum TG level in Kaplan–Meier curve analysis (P < 0.001, by Log-rank test). Cox regression analysis demonstrated that, compared to that of the 1st quartile, the risk of composite renal event was significantly higher in the 4th quartile (adjusted hazard ratio 1.433, 95% confidence interval 1.046 to 1.964). The association between high serum TG level and adverse renal outcome remained consistent in the cause-specific hazard model. Subgroup analyses revealed that the association is modified by age, estimated glomerular filtration rate, and spot urine albumin-to-creatinine ratio. In conclusion, high serum TG level is independently associated with adverse renal outcomes in patients with non-dialysis CKD. Interventional studies are warranted to determine whether lowering serum TG levels may alter the natural course of CKD.
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spelling pubmed-97297692022-12-09 Serum triglycerides level is independently associated with renal outcomes in patients with non-dialysis chronic kidney disease: Results from KNOW-CKD study Suh, Sang Heon Oh, Tae Ryom Choi, Hong Sang Kim, Chang Seong Bae, Eun Hui Oh, Kook-Hwan Han, Seung Hyeok Ma, Seong Kwon Kim, Soo Wan Front Nutr Nutrition To investigate whether high serum triglycerides (TG) level is associated with adverse renal outcomes in patients with non-dialysis chronic kidney disease (CKD), a total of 2,158 subjects from a prospective cohort study (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease) were divided into the quartile by serum TG level. The primary outcomes were composite renal events, which is defined as a composite of decline of kidney function (the first occurrence of > 50% decline of estimated glomerular filtration rate or doubling of serum creatinine from the baseline) or onset of end-stage renal disease (initiation of dialysis or kidney transplantation). During the median follow-up of 6.940 years, the cumulative incidence of composite renal event was significantly differed by serum TG level in Kaplan–Meier curve analysis (P < 0.001, by Log-rank test). Cox regression analysis demonstrated that, compared to that of the 1st quartile, the risk of composite renal event was significantly higher in the 4th quartile (adjusted hazard ratio 1.433, 95% confidence interval 1.046 to 1.964). The association between high serum TG level and adverse renal outcome remained consistent in the cause-specific hazard model. Subgroup analyses revealed that the association is modified by age, estimated glomerular filtration rate, and spot urine albumin-to-creatinine ratio. In conclusion, high serum TG level is independently associated with adverse renal outcomes in patients with non-dialysis CKD. Interventional studies are warranted to determine whether lowering serum TG levels may alter the natural course of CKD. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9729769/ /pubmed/36505239 http://dx.doi.org/10.3389/fnut.2022.1037618 Text en Copyright © 2022 Suh, Oh, Choi, Kim, Bae, Oh, Han, Ma and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Suh, Sang Heon
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Bae, Eun Hui
Oh, Kook-Hwan
Han, Seung Hyeok
Ma, Seong Kwon
Kim, Soo Wan
Serum triglycerides level is independently associated with renal outcomes in patients with non-dialysis chronic kidney disease: Results from KNOW-CKD study
title Serum triglycerides level is independently associated with renal outcomes in patients with non-dialysis chronic kidney disease: Results from KNOW-CKD study
title_full Serum triglycerides level is independently associated with renal outcomes in patients with non-dialysis chronic kidney disease: Results from KNOW-CKD study
title_fullStr Serum triglycerides level is independently associated with renal outcomes in patients with non-dialysis chronic kidney disease: Results from KNOW-CKD study
title_full_unstemmed Serum triglycerides level is independently associated with renal outcomes in patients with non-dialysis chronic kidney disease: Results from KNOW-CKD study
title_short Serum triglycerides level is independently associated with renal outcomes in patients with non-dialysis chronic kidney disease: Results from KNOW-CKD study
title_sort serum triglycerides level is independently associated with renal outcomes in patients with non-dialysis chronic kidney disease: results from know-ckd study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729769/
https://www.ncbi.nlm.nih.gov/pubmed/36505239
http://dx.doi.org/10.3389/fnut.2022.1037618
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