Estrogen-related receptor alpha drives mitochondrial biogenesis and resistance to neoadjuvant chemoradiation in esophageal cancer

Neoadjuvant chemoradiotherapy (nCRT) improves outcomes in resectable esophageal adenocarcinoma (EAC), but acquired resistance precludes long-term efficacy. Here, we delineate these resistance mechanisms. RNA sequencing on matched patient samples obtained pre-and post-neoadjuvant treatment reveal tha...

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Detalles Bibliográficos
Autores principales: Dings, Mark P.G., van der Zalm, Amber P., Bootsma, Sanne, van Maanen, Tatum F.J., Waasdorp, Cynthia, van den Ende, Tom, Liu, Dajia, Bailey, Peter, Koster, Jan, Zwijnenburg, Danny A., Spek, C. Arnold, Klomp, Jan P.G., Oubrie, Arthur, Hooijer, Gerrit K.J., Meijer, Sybren L., van Berge Henegouwen, Mark I., Hulshof, Maarten C., Bergman, Jacques, Oyarce, Cesar, Medema, Jan Paul, van Laarhoven, Hanneke W.M., Bijlsma, Maarten F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729822/
https://www.ncbi.nlm.nih.gov/pubmed/36334593
http://dx.doi.org/10.1016/j.xcrm.2022.100802

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