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AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure

Leydig cell failure (LCF) caused by gene mutation results in testosterone deficiency and infertility. Serum testosterone levels can be recovered via testosterone replacement; however, established therapies have shown limited success in restoring fertility. Here, we use a luteinizing hormone/choriogo...

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Detalles Bibliográficos
Autores principales:	Xia, Kai, Wang, Fulin, Lai, Xingqiang, Dong, Lin, Luo, Peng, Zhang, Suyuan, Yang, Cuifeng, Chen, Hong, Ma, Yuanchen, Huang, Weijun, Ou, Wangsheng, Li, Yuyan, Feng, Xin, Yang, Bin, Liu, Congyuan, Lei, Zhenmin, Tu, Xiang’an, Ke, Qiong, Mao, Frank Fuxiang, Deng, Chunhua, Xiang, Andy Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729833/ https://www.ncbi.nlm.nih.gov/pubmed/36270285 http://dx.doi.org/10.1016/j.xcrm.2022.100792

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