Identifying inflammatory phenotypes to target mechanism-specific treatments in sepsis

A clinical trial by Leventogiannis et al.(1) suggests that ferritin and HLA-DR monocyte receptor expression can identify septic patients with macrophage-activation-like syndrome (MALS), or immunoparalysis, and that targeting IL-1ra treatment with this strategy may improve outcomes.

Detalles Bibliográficos
Autores principales: Gómez, Hernando, Anderko, Renee R., Carcillo, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729868/
https://www.ncbi.nlm.nih.gov/pubmed/36384087
http://dx.doi.org/10.1016/j.xcrm.2022.100823
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author Gómez, Hernando
Anderko, Renee R.
Carcillo, Joseph A.
author_facet Gómez, Hernando
Anderko, Renee R.
Carcillo, Joseph A.
author_sort Gómez, Hernando
collection PubMed
description A clinical trial by Leventogiannis et al.(1) suggests that ferritin and HLA-DR monocyte receptor expression can identify septic patients with macrophage-activation-like syndrome (MALS), or immunoparalysis, and that targeting IL-1ra treatment with this strategy may improve outcomes.
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spelling pubmed-97298682022-12-09 Identifying inflammatory phenotypes to target mechanism-specific treatments in sepsis Gómez, Hernando Anderko, Renee R. Carcillo, Joseph A. Cell Rep Med Preview A clinical trial by Leventogiannis et al.(1) suggests that ferritin and HLA-DR monocyte receptor expression can identify septic patients with macrophage-activation-like syndrome (MALS), or immunoparalysis, and that targeting IL-1ra treatment with this strategy may improve outcomes. Elsevier 2022-11-15 /pmc/articles/PMC9729868/ /pubmed/36384087 http://dx.doi.org/10.1016/j.xcrm.2022.100823 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Gómez, Hernando
Anderko, Renee R.
Carcillo, Joseph A.
Identifying inflammatory phenotypes to target mechanism-specific treatments in sepsis
title Identifying inflammatory phenotypes to target mechanism-specific treatments in sepsis
title_full Identifying inflammatory phenotypes to target mechanism-specific treatments in sepsis
title_fullStr Identifying inflammatory phenotypes to target mechanism-specific treatments in sepsis
title_full_unstemmed Identifying inflammatory phenotypes to target mechanism-specific treatments in sepsis
title_short Identifying inflammatory phenotypes to target mechanism-specific treatments in sepsis
title_sort identifying inflammatory phenotypes to target mechanism-specific treatments in sepsis
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729868/
https://www.ncbi.nlm.nih.gov/pubmed/36384087
http://dx.doi.org/10.1016/j.xcrm.2022.100823
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