Proteogenomic analysis of lung adenocarcinoma reveals tumor heterogeneity, survival determinants, and therapeutically relevant pathways

We present a deep proteogenomic profiling study of 87 lung adenocarcinoma (LUAD) tumors from the United States, integrating whole-genome sequencing, transcriptome sequencing, proteomics and phosphoproteomics by mass spectrometry, and reverse-phase protein arrays. We identify three subtypes from soma...

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Detalles Bibliográficos
Autores principales: Soltis, Anthony R., Bateman, Nicholas W., Liu, Jianfang, Nguyen, Trinh, Franks, Teri J., Zhang, Xijun, Dalgard, Clifton L., Viollet, Coralie, Somiari, Stella, Yan, Chunhua, Zeman, Karen, Skinner, William J., Lee, Jerry S.H., Pollard, Harvey B., Turner, Clesson, Petricoin, Emanuel F., Meerzaman, Daoud, Conrads, Thomas P., Hu, Hai, Shriver, Craig D., Moskaluk, Christopher A., Browning, Robert F., Wilkerson, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729884/
https://www.ncbi.nlm.nih.gov/pubmed/36384096
http://dx.doi.org/10.1016/j.xcrm.2022.100819

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