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Adenosine reduces sinoatrial node cell action potential firing rate by uncoupling its membrane and calcium clocks
The spontaneous action potential (AP) firing rate of sinoatrial nodal cells (SANC) is regulated by a system of intracellular Ca(2+) and membrane ion current clocks driven by Ca(2+)-calmodulin-activated adenylyl cyclase-protein kinase-A signaling. The mean AP-cycle length (APCL) and APCL variability...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730041/ https://www.ncbi.nlm.nih.gov/pubmed/36505046 http://dx.doi.org/10.3389/fphys.2022.977807 |