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Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field

Two-microbubble collapse near a spherical cell in an ultrasonic field is numerically analyzed by extending a level-set method for compressible multiphase flows with bubble and cell multiple interfaces. Computations performed with different bubble-bubble distances and size ratios demonstrate various...

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Detalles Bibliográficos
Autores principales: Hong, Seongjin, Son, Gihun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730221/
https://www.ncbi.nlm.nih.gov/pubmed/36495781
http://dx.doi.org/10.1016/j.ultsonch.2022.106252
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author Hong, Seongjin
Son, Gihun
author_facet Hong, Seongjin
Son, Gihun
author_sort Hong, Seongjin
collection PubMed
description Two-microbubble collapse near a spherical cell in an ultrasonic field is numerically analyzed by extending a level-set method for compressible multiphase flows with bubble and cell multiple interfaces. Computations performed with different bubble-bubble distances and size ratios demonstrate various bubble-bubble interactions, such as bubble coalescence, bubble repulsion and attraction, jet penetration into the bubble, and jet collision. The interactions between collapsing bubbles are found to produce strong liquid jet formation and result in significant cell deformation compared to single-bubble collapse. The optimal bubble-bubble distance and size ratio for cell deformation are presented via contour maps based on extensive computations. The influences of the ultrasonic amplitude and frequency on cell deformation are further investigated.
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spelling pubmed-97302212022-12-09 Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field Hong, Seongjin Son, Gihun Ultrason Sonochem Original Research Article Two-microbubble collapse near a spherical cell in an ultrasonic field is numerically analyzed by extending a level-set method for compressible multiphase flows with bubble and cell multiple interfaces. Computations performed with different bubble-bubble distances and size ratios demonstrate various bubble-bubble interactions, such as bubble coalescence, bubble repulsion and attraction, jet penetration into the bubble, and jet collision. The interactions between collapsing bubbles are found to produce strong liquid jet formation and result in significant cell deformation compared to single-bubble collapse. The optimal bubble-bubble distance and size ratio for cell deformation are presented via contour maps based on extensive computations. The influences of the ultrasonic amplitude and frequency on cell deformation are further investigated. Elsevier 2022-12-06 /pmc/articles/PMC9730221/ /pubmed/36495781 http://dx.doi.org/10.1016/j.ultsonch.2022.106252 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research Article
Hong, Seongjin
Son, Gihun
Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field
title Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field
title_full Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field
title_fullStr Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field
title_full_unstemmed Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field
title_short Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field
title_sort numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730221/
https://www.ncbi.nlm.nih.gov/pubmed/36495781
http://dx.doi.org/10.1016/j.ultsonch.2022.106252
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