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Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field
Two-microbubble collapse near a spherical cell in an ultrasonic field is numerically analyzed by extending a level-set method for compressible multiphase flows with bubble and cell multiple interfaces. Computations performed with different bubble-bubble distances and size ratios demonstrate various...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730221/ https://www.ncbi.nlm.nih.gov/pubmed/36495781 http://dx.doi.org/10.1016/j.ultsonch.2022.106252 |
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author | Hong, Seongjin Son, Gihun |
author_facet | Hong, Seongjin Son, Gihun |
author_sort | Hong, Seongjin |
collection | PubMed |
description | Two-microbubble collapse near a spherical cell in an ultrasonic field is numerically analyzed by extending a level-set method for compressible multiphase flows with bubble and cell multiple interfaces. Computations performed with different bubble-bubble distances and size ratios demonstrate various bubble-bubble interactions, such as bubble coalescence, bubble repulsion and attraction, jet penetration into the bubble, and jet collision. The interactions between collapsing bubbles are found to produce strong liquid jet formation and result in significant cell deformation compared to single-bubble collapse. The optimal bubble-bubble distance and size ratio for cell deformation are presented via contour maps based on extensive computations. The influences of the ultrasonic amplitude and frequency on cell deformation are further investigated. |
format | Online Article Text |
id | pubmed-9730221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-97302212022-12-09 Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field Hong, Seongjin Son, Gihun Ultrason Sonochem Original Research Article Two-microbubble collapse near a spherical cell in an ultrasonic field is numerically analyzed by extending a level-set method for compressible multiphase flows with bubble and cell multiple interfaces. Computations performed with different bubble-bubble distances and size ratios demonstrate various bubble-bubble interactions, such as bubble coalescence, bubble repulsion and attraction, jet penetration into the bubble, and jet collision. The interactions between collapsing bubbles are found to produce strong liquid jet formation and result in significant cell deformation compared to single-bubble collapse. The optimal bubble-bubble distance and size ratio for cell deformation are presented via contour maps based on extensive computations. The influences of the ultrasonic amplitude and frequency on cell deformation are further investigated. Elsevier 2022-12-06 /pmc/articles/PMC9730221/ /pubmed/36495781 http://dx.doi.org/10.1016/j.ultsonch.2022.106252 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Research Article Hong, Seongjin Son, Gihun Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field |
title | Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field |
title_full | Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field |
title_fullStr | Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field |
title_full_unstemmed | Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field |
title_short | Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field |
title_sort | numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730221/ https://www.ncbi.nlm.nih.gov/pubmed/36495781 http://dx.doi.org/10.1016/j.ultsonch.2022.106252 |
work_keys_str_mv | AT hongseongjin numericalinvestigationoftwomicrobubblecollapseandcelldeformationinanultrasonicfield AT songihun numericalinvestigationoftwomicrobubblecollapseandcelldeformationinanultrasonicfield |