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Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC

Pharmacological inhibition of the Nod-like receptor family protein 3 (NLRP3) inflammasome contributes to the treatment of numerous inflammation-related diseases, making it a desirable drug target. Spirodalesol, derived from the ascomycete fungus Daldinia eschscholzii, has been reported to inhibit NL...

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Detalles Bibliográficos
Autores principales:	Liu, Wen, Yang, Jiashu, Fang, Shihao, Jiao, Chenyang, Gao, Jianhua, Zhang, Aihua, Wu, Tiancong, Tan, Renxiang, Xu, Qiang, Guo, Wenjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730227/ https://www.ncbi.nlm.nih.gov/pubmed/36379253 http://dx.doi.org/10.1016/j.jbc.2022.102696

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