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Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry Approach to Correlate Local Structure and Aggregation in α-Synuclein

[Image: see text] In Parkinson’s disease and other synucleinopathies, α-synuclein misfolds and aggregates. Its intrinsically disordered nature, however, causes it to adopt several meta-stable conformations stabilized by internal hydrogen bonding. Because they interconvert on short timescales, monome...

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Detalles Bibliográficos
Autores principales:	Seetaloo, Neeleema, Zacharopoulou, Maria, Stephens, Amberley D., Kaminski Schierle, Gabriele S., Phillips, Jonathan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730295/ https://www.ncbi.nlm.nih.gov/pubmed/36413494 http://dx.doi.org/10.1021/acs.analchem.2c03183

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