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Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome

BACKGROUND: Gallstone disease is a common gastrointestinal disorder, which has previously been reported to be associated with the incidence of cardiovascular disease. We aimed to investigate the association between gallstone disease and long-term outcomes in patients with acute coronary syndrome (AC...

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Autores principales: Su, Wen, Zhu, Jie-Gao, Li, Wei-Ping, Chen, Hui, Li, Hong-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730328/
https://www.ncbi.nlm.nih.gov/pubmed/36505391
http://dx.doi.org/10.3389/fcvm.2022.1033959
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author Su, Wen
Zhu, Jie-Gao
Li, Wei-Ping
Chen, Hui
Li, Hong-Wei
author_facet Su, Wen
Zhu, Jie-Gao
Li, Wei-Ping
Chen, Hui
Li, Hong-Wei
author_sort Su, Wen
collection PubMed
description BACKGROUND: Gallstone disease is a common gastrointestinal disorder, which has previously been reported to be associated with the incidence of cardiovascular disease. We aimed to investigate the association between gallstone disease and long-term outcomes in patients with acute coronary syndrome (ACS). MATERIALS AND METHODS: A total of consecutive 13,975 ACS patients were included in this analysis. Gallstone disease in our study included both gallstones and cholecystectomy. The primary endpoint was cardiac mortality. The secondary outcome was all-cause mortality. Relative risks were estimated using Cox proportional hazards regression. RESULTS: During a median follow-up period of 2.96 years, 518 (4.2%) patients without gallstone disease and 62 (3.6%) patients in those with gallstone disease suffered cardiac death. After multivariable adjustment for established risk factors, subjects with gallstone disease had decreased risks of both cardiac mortality and all-cause mortality [hazard rate ratios (HR) = 0.72, 95% CI: 0.55–0.95 and HR = 0.75, 95% CI: 0.62–0.90, respectively]. In patients with performed cholecystectomy, the associations between gallstones and risks for cardiac mortality and all-cause mortality turned out to be non-significant. HRs varied across subgroups depending on the presence of selected established risk factors. CONCLUSION: Presence of gallstone disease was associated with a significantly decreased risk of follow-up mortality in patients with ACS.
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spelling pubmed-97303282022-12-09 Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome Su, Wen Zhu, Jie-Gao Li, Wei-Ping Chen, Hui Li, Hong-Wei Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Gallstone disease is a common gastrointestinal disorder, which has previously been reported to be associated with the incidence of cardiovascular disease. We aimed to investigate the association between gallstone disease and long-term outcomes in patients with acute coronary syndrome (ACS). MATERIALS AND METHODS: A total of consecutive 13,975 ACS patients were included in this analysis. Gallstone disease in our study included both gallstones and cholecystectomy. The primary endpoint was cardiac mortality. The secondary outcome was all-cause mortality. Relative risks were estimated using Cox proportional hazards regression. RESULTS: During a median follow-up period of 2.96 years, 518 (4.2%) patients without gallstone disease and 62 (3.6%) patients in those with gallstone disease suffered cardiac death. After multivariable adjustment for established risk factors, subjects with gallstone disease had decreased risks of both cardiac mortality and all-cause mortality [hazard rate ratios (HR) = 0.72, 95% CI: 0.55–0.95 and HR = 0.75, 95% CI: 0.62–0.90, respectively]. In patients with performed cholecystectomy, the associations between gallstones and risks for cardiac mortality and all-cause mortality turned out to be non-significant. HRs varied across subgroups depending on the presence of selected established risk factors. CONCLUSION: Presence of gallstone disease was associated with a significantly decreased risk of follow-up mortality in patients with ACS. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9730328/ /pubmed/36505391 http://dx.doi.org/10.3389/fcvm.2022.1033959 Text en Copyright © 2022 Su, Zhu, Li, Chen and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Su, Wen
Zhu, Jie-Gao
Li, Wei-Ping
Chen, Hui
Li, Hong-Wei
Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome
title Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome
title_full Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome
title_fullStr Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome
title_full_unstemmed Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome
title_short Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome
title_sort gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730328/
https://www.ncbi.nlm.nih.gov/pubmed/36505391
http://dx.doi.org/10.3389/fcvm.2022.1033959
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