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Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?
Klebsiella pneumoniae (K. pneumoniae) is a typical gram-negative iatrogenic bacterium that often causes bacteremia, pneumonia and urinary tract infection particularly among those with low immunity. Although antibiotics is the cornerstone of anti-infections, the clinical efficacy of β-lactamase and c...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730340/ https://www.ncbi.nlm.nih.gov/pubmed/36506034 http://dx.doi.org/10.3389/fcimb.2022.1050396 |
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author | Liang, Zihan Wang, Yiyao Lai, Yixiang Zhang, Jingyi Yin, Lanlan Yu, Xiang Zhou, Yongqin Li, Xinzhi Song, Yinhong |
author_facet | Liang, Zihan Wang, Yiyao Lai, Yixiang Zhang, Jingyi Yin, Lanlan Yu, Xiang Zhou, Yongqin Li, Xinzhi Song, Yinhong |
author_sort | Liang, Zihan |
collection | PubMed |
description | Klebsiella pneumoniae (K. pneumoniae) is a typical gram-negative iatrogenic bacterium that often causes bacteremia, pneumonia and urinary tract infection particularly among those with low immunity. Although antibiotics is the cornerstone of anti-infections, the clinical efficacy of β-lactamase and carbapenems drugs has been weakened due to the emergence of drug-resistant K. pneumoniae. Recent studies have demonstrated that host defense plays a critical role in killing K. pneumoniae. Here, we summarize our current understanding of host immunity mechanisms against K. pneumoniae, including mechanical barrier, innate immune cells, cellular immunity and humoral immunity, providing a theoretical basis and the new strategy for the clinical treatment of K. pneumoniae through improving host immunity. |
format | Online Article Text |
id | pubmed-9730340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97303402022-12-09 Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics? Liang, Zihan Wang, Yiyao Lai, Yixiang Zhang, Jingyi Yin, Lanlan Yu, Xiang Zhou, Yongqin Li, Xinzhi Song, Yinhong Front Cell Infect Microbiol Cellular and Infection Microbiology Klebsiella pneumoniae (K. pneumoniae) is a typical gram-negative iatrogenic bacterium that often causes bacteremia, pneumonia and urinary tract infection particularly among those with low immunity. Although antibiotics is the cornerstone of anti-infections, the clinical efficacy of β-lactamase and carbapenems drugs has been weakened due to the emergence of drug-resistant K. pneumoniae. Recent studies have demonstrated that host defense plays a critical role in killing K. pneumoniae. Here, we summarize our current understanding of host immunity mechanisms against K. pneumoniae, including mechanical barrier, innate immune cells, cellular immunity and humoral immunity, providing a theoretical basis and the new strategy for the clinical treatment of K. pneumoniae through improving host immunity. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9730340/ /pubmed/36506034 http://dx.doi.org/10.3389/fcimb.2022.1050396 Text en Copyright © 2022 Liang, Wang, Lai, Zhang, Yin, Yu, Zhou, Li and Song https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Liang, Zihan Wang, Yiyao Lai, Yixiang Zhang, Jingyi Yin, Lanlan Yu, Xiang Zhou, Yongqin Li, Xinzhi Song, Yinhong Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics? |
title | Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics? |
title_full | Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics? |
title_fullStr | Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics? |
title_full_unstemmed | Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics? |
title_short | Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics? |
title_sort | host defense against the infection of klebsiella pneumoniae: new strategy to kill the bacterium in the era of antibiotics? |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730340/ https://www.ncbi.nlm.nih.gov/pubmed/36506034 http://dx.doi.org/10.3389/fcimb.2022.1050396 |
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