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Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?

Klebsiella pneumoniae (K. pneumoniae) is a typical gram-negative iatrogenic bacterium that often causes bacteremia, pneumonia and urinary tract infection particularly among those with low immunity. Although antibiotics is the cornerstone of anti-infections, the clinical efficacy of β-lactamase and c...

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Autores principales: Liang, Zihan, Wang, Yiyao, Lai, Yixiang, Zhang, Jingyi, Yin, Lanlan, Yu, Xiang, Zhou, Yongqin, Li, Xinzhi, Song, Yinhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730340/
https://www.ncbi.nlm.nih.gov/pubmed/36506034
http://dx.doi.org/10.3389/fcimb.2022.1050396
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author Liang, Zihan
Wang, Yiyao
Lai, Yixiang
Zhang, Jingyi
Yin, Lanlan
Yu, Xiang
Zhou, Yongqin
Li, Xinzhi
Song, Yinhong
author_facet Liang, Zihan
Wang, Yiyao
Lai, Yixiang
Zhang, Jingyi
Yin, Lanlan
Yu, Xiang
Zhou, Yongqin
Li, Xinzhi
Song, Yinhong
author_sort Liang, Zihan
collection PubMed
description Klebsiella pneumoniae (K. pneumoniae) is a typical gram-negative iatrogenic bacterium that often causes bacteremia, pneumonia and urinary tract infection particularly among those with low immunity. Although antibiotics is the cornerstone of anti-infections, the clinical efficacy of β-lactamase and carbapenems drugs has been weakened due to the emergence of drug-resistant K. pneumoniae. Recent studies have demonstrated that host defense plays a critical role in killing K. pneumoniae. Here, we summarize our current understanding of host immunity mechanisms against K. pneumoniae, including mechanical barrier, innate immune cells, cellular immunity and humoral immunity, providing a theoretical basis and the new strategy for the clinical treatment of K. pneumoniae through improving host immunity.
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spelling pubmed-97303402022-12-09 Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics? Liang, Zihan Wang, Yiyao Lai, Yixiang Zhang, Jingyi Yin, Lanlan Yu, Xiang Zhou, Yongqin Li, Xinzhi Song, Yinhong Front Cell Infect Microbiol Cellular and Infection Microbiology Klebsiella pneumoniae (K. pneumoniae) is a typical gram-negative iatrogenic bacterium that often causes bacteremia, pneumonia and urinary tract infection particularly among those with low immunity. Although antibiotics is the cornerstone of anti-infections, the clinical efficacy of β-lactamase and carbapenems drugs has been weakened due to the emergence of drug-resistant K. pneumoniae. Recent studies have demonstrated that host defense plays a critical role in killing K. pneumoniae. Here, we summarize our current understanding of host immunity mechanisms against K. pneumoniae, including mechanical barrier, innate immune cells, cellular immunity and humoral immunity, providing a theoretical basis and the new strategy for the clinical treatment of K. pneumoniae through improving host immunity. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9730340/ /pubmed/36506034 http://dx.doi.org/10.3389/fcimb.2022.1050396 Text en Copyright © 2022 Liang, Wang, Lai, Zhang, Yin, Yu, Zhou, Li and Song https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Liang, Zihan
Wang, Yiyao
Lai, Yixiang
Zhang, Jingyi
Yin, Lanlan
Yu, Xiang
Zhou, Yongqin
Li, Xinzhi
Song, Yinhong
Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?
title Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?
title_full Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?
title_fullStr Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?
title_full_unstemmed Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?
title_short Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?
title_sort host defense against the infection of klebsiella pneumoniae: new strategy to kill the bacterium in the era of antibiotics?
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730340/
https://www.ncbi.nlm.nih.gov/pubmed/36506034
http://dx.doi.org/10.3389/fcimb.2022.1050396
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