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Biocompatible and Printable Ionotronic Sensing Materials Based on Silk Fibroin and Soluble Plant-Derived Polyphenols

[Image: see text] The emergence of ionotronic materials has been recently exploited for interfacing electronics and biological tissues, improving sensing with the surrounding environment. In this paper, we investigated the synergistic effect of regenerated silk fibroin (RS) with a plant-derived poly...

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Autores principales: Chiesa, Irene, De Maria, Carmelo, Tonin, Rodolfo, Ripanti, Francesca, Ceccarini, Maria Rachele, Salvatori, Carlotta, Mussolin, Lorenzo, Paciaroni, Alessandro, Petrillo, Caterina, Cesprini, Emanuele, Feo, Federica, Calamai, Martino, Morrone, Amelia, Morabito, Antonino, Beccari, Tommaso, Valentini, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730456/
https://www.ncbi.nlm.nih.gov/pubmed/36506141
http://dx.doi.org/10.1021/acsomega.2c04729
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author Chiesa, Irene
De Maria, Carmelo
Tonin, Rodolfo
Ripanti, Francesca
Ceccarini, Maria Rachele
Salvatori, Carlotta
Mussolin, Lorenzo
Paciaroni, Alessandro
Petrillo, Caterina
Cesprini, Emanuele
Feo, Federica
Calamai, Martino
Morrone, Amelia
Morabito, Antonino
Beccari, Tommaso
Valentini, Luca
author_facet Chiesa, Irene
De Maria, Carmelo
Tonin, Rodolfo
Ripanti, Francesca
Ceccarini, Maria Rachele
Salvatori, Carlotta
Mussolin, Lorenzo
Paciaroni, Alessandro
Petrillo, Caterina
Cesprini, Emanuele
Feo, Federica
Calamai, Martino
Morrone, Amelia
Morabito, Antonino
Beccari, Tommaso
Valentini, Luca
author_sort Chiesa, Irene
collection PubMed
description [Image: see text] The emergence of ionotronic materials has been recently exploited for interfacing electronics and biological tissues, improving sensing with the surrounding environment. In this paper, we investigated the synergistic effect of regenerated silk fibroin (RS) with a plant-derived polyphenol (i.e., chestnut tannin) on ionic conductivity and how water molecules play critical roles in regulating ion mobility in these materials. In particular, we observed that adding tannin to RS increases the ionic conductivity, and this phenomenon is accentuated by increasing the hydration. We also demonstrated how silk-based hybrids could be used as building materials for scaffolds where human fibroblast and neural progenitor cells can highly proliferate. Finally, after proving their biocompatibility, RS hybrids demonstrate excellent three-dimensional (3D) printability via extrusion-based 3D printing to fabricate a soft sensor that can detect charged objects by sensing the electric fields that originate from them. These findings pave the way for a viable option for cell culture and novel sensors, with the potential base for tissue engineering and health monitoring.
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spelling pubmed-97304562022-12-09 Biocompatible and Printable Ionotronic Sensing Materials Based on Silk Fibroin and Soluble Plant-Derived Polyphenols Chiesa, Irene De Maria, Carmelo Tonin, Rodolfo Ripanti, Francesca Ceccarini, Maria Rachele Salvatori, Carlotta Mussolin, Lorenzo Paciaroni, Alessandro Petrillo, Caterina Cesprini, Emanuele Feo, Federica Calamai, Martino Morrone, Amelia Morabito, Antonino Beccari, Tommaso Valentini, Luca ACS Omega [Image: see text] The emergence of ionotronic materials has been recently exploited for interfacing electronics and biological tissues, improving sensing with the surrounding environment. In this paper, we investigated the synergistic effect of regenerated silk fibroin (RS) with a plant-derived polyphenol (i.e., chestnut tannin) on ionic conductivity and how water molecules play critical roles in regulating ion mobility in these materials. In particular, we observed that adding tannin to RS increases the ionic conductivity, and this phenomenon is accentuated by increasing the hydration. We also demonstrated how silk-based hybrids could be used as building materials for scaffolds where human fibroblast and neural progenitor cells can highly proliferate. Finally, after proving their biocompatibility, RS hybrids demonstrate excellent three-dimensional (3D) printability via extrusion-based 3D printing to fabricate a soft sensor that can detect charged objects by sensing the electric fields that originate from them. These findings pave the way for a viable option for cell culture and novel sensors, with the potential base for tissue engineering and health monitoring. American Chemical Society 2022-11-28 /pmc/articles/PMC9730456/ /pubmed/36506141 http://dx.doi.org/10.1021/acsomega.2c04729 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Chiesa, Irene
De Maria, Carmelo
Tonin, Rodolfo
Ripanti, Francesca
Ceccarini, Maria Rachele
Salvatori, Carlotta
Mussolin, Lorenzo
Paciaroni, Alessandro
Petrillo, Caterina
Cesprini, Emanuele
Feo, Federica
Calamai, Martino
Morrone, Amelia
Morabito, Antonino
Beccari, Tommaso
Valentini, Luca
Biocompatible and Printable Ionotronic Sensing Materials Based on Silk Fibroin and Soluble Plant-Derived Polyphenols
title Biocompatible and Printable Ionotronic Sensing Materials Based on Silk Fibroin and Soluble Plant-Derived Polyphenols
title_full Biocompatible and Printable Ionotronic Sensing Materials Based on Silk Fibroin and Soluble Plant-Derived Polyphenols
title_fullStr Biocompatible and Printable Ionotronic Sensing Materials Based on Silk Fibroin and Soluble Plant-Derived Polyphenols
title_full_unstemmed Biocompatible and Printable Ionotronic Sensing Materials Based on Silk Fibroin and Soluble Plant-Derived Polyphenols
title_short Biocompatible and Printable Ionotronic Sensing Materials Based on Silk Fibroin and Soluble Plant-Derived Polyphenols
title_sort biocompatible and printable ionotronic sensing materials based on silk fibroin and soluble plant-derived polyphenols
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730456/
https://www.ncbi.nlm.nih.gov/pubmed/36506141
http://dx.doi.org/10.1021/acsomega.2c04729
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