Case report: Evolution of pulmonary manifestations and virological markers in critical COVID-19 infection in Bruton’s agammaglobulinemia

Despite several reports and small case series on the disease course of SARS-CoV-2 infection in patients with inborn errors of immunity (IEI), including X-linked agammaglobulinemia (XLA), this topic remains incompletely described. Here we present the case of a 38-year-old unvaccinated man with XLA, w...

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Autores principales: Rise, Nina, Touborg, Toke, Lundsted, Ditte Helene, Dalager-Pedersen, Michael, Mogensen, Trine H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730530/
https://www.ncbi.nlm.nih.gov/pubmed/36505407
http://dx.doi.org/10.3389/fimmu.2022.1057065
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author Rise, Nina
Touborg, Toke
Lundsted, Ditte Helene
Dalager-Pedersen, Michael
Mogensen, Trine H.
author_facet Rise, Nina
Touborg, Toke
Lundsted, Ditte Helene
Dalager-Pedersen, Michael
Mogensen, Trine H.
author_sort Rise, Nina
collection PubMed
description Despite several reports and small case series on the disease course of SARS-CoV-2 infection in patients with inborn errors of immunity (IEI), including X-linked agammaglobulinemia (XLA), this topic remains incompletely described. Here we present the case of a 38-year-old unvaccinated man with XLA, who acquired SARS-CoV-2 infection and experienced a protracted disease course with 47 days of SARS-CoV-2 positivity, critical COVID-19 with respiratory insufficiency necessitating intensive care and ventilatory support, and prompting repeated intensified treatments with remdesivir, dexamethasone, and monoclonal antibodies to eventually control infection. We describe the disease course and treatment and review the current literature on COVID-19 susceptibility and evidence for vaccine efficacy in patients with XLA.
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spelling pubmed-97305302022-12-09 Case report: Evolution of pulmonary manifestations and virological markers in critical COVID-19 infection in Bruton’s agammaglobulinemia Rise, Nina Touborg, Toke Lundsted, Ditte Helene Dalager-Pedersen, Michael Mogensen, Trine H. Front Immunol Immunology Despite several reports and small case series on the disease course of SARS-CoV-2 infection in patients with inborn errors of immunity (IEI), including X-linked agammaglobulinemia (XLA), this topic remains incompletely described. Here we present the case of a 38-year-old unvaccinated man with XLA, who acquired SARS-CoV-2 infection and experienced a protracted disease course with 47 days of SARS-CoV-2 positivity, critical COVID-19 with respiratory insufficiency necessitating intensive care and ventilatory support, and prompting repeated intensified treatments with remdesivir, dexamethasone, and monoclonal antibodies to eventually control infection. We describe the disease course and treatment and review the current literature on COVID-19 susceptibility and evidence for vaccine efficacy in patients with XLA. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9730530/ /pubmed/36505407 http://dx.doi.org/10.3389/fimmu.2022.1057065 Text en Copyright © 2022 Rise, Touborg, Lundsted, Dalager-Pedersen and Mogensen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Rise, Nina
Touborg, Toke
Lundsted, Ditte Helene
Dalager-Pedersen, Michael
Mogensen, Trine H.
Case report: Evolution of pulmonary manifestations and virological markers in critical COVID-19 infection in Bruton’s agammaglobulinemia
title Case report: Evolution of pulmonary manifestations and virological markers in critical COVID-19 infection in Bruton’s agammaglobulinemia
title_full Case report: Evolution of pulmonary manifestations and virological markers in critical COVID-19 infection in Bruton’s agammaglobulinemia
title_fullStr Case report: Evolution of pulmonary manifestations and virological markers in critical COVID-19 infection in Bruton’s agammaglobulinemia
title_full_unstemmed Case report: Evolution of pulmonary manifestations and virological markers in critical COVID-19 infection in Bruton’s agammaglobulinemia
title_short Case report: Evolution of pulmonary manifestations and virological markers in critical COVID-19 infection in Bruton’s agammaglobulinemia
title_sort case report: evolution of pulmonary manifestations and virological markers in critical covid-19 infection in bruton’s agammaglobulinemia
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730530/
https://www.ncbi.nlm.nih.gov/pubmed/36505407
http://dx.doi.org/10.3389/fimmu.2022.1057065
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