BI-847325, a selective dual MEK and Aurora kinases inhibitor, reduces aggressive behavior of anaplastic thyroid carcinoma on an in vitro three-dimensional culture

BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the most aggressive subtype of thyroid cancer. In this study, we used a three-dimensional in vitro system to evaluate the effect of a dual MEK/Aurora kinase inhibitor, BI-847325 anticancer drug, on several cellular and molecular processes involved in...

Descripción completa

Detalles Bibliográficos
Autores principales: Samimi, Hilda, Tavakoli, Rezvan, Fallah, Parviz, Naderi Sohi, Alireza, Amini Shirkouhi, Maryam, Naderi, Mahmood, Haghpanah, Vahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730667/
https://www.ncbi.nlm.nih.gov/pubmed/36482411
http://dx.doi.org/10.1186/s12935-022-02813-6

Ejemplares similares

Ejemplares similares