Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats

BACKGROUND: Allopurinol is used to treat hyperuricemia and gout. It is metabolized to oxypurinol by xanthine oxidase (XO), and aldehyde oxidase (AO). Allopurinol and oxypurinol are potent XO inhibitors that reduce the plasma uric acid levels. Although oxypurinol levels show large inter-individual va...

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Detalles Bibliográficos
Autores principales: Tayama, Yoshitaka, Sugihara, Kazumi, Sanoh, Seigo, Miyake, Katsushi, Kitamura, Shigeyuki, Ohta, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730672/
https://www.ncbi.nlm.nih.gov/pubmed/36476607
http://dx.doi.org/10.1186/s40780-022-00262-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730672/
https://www.ncbi.nlm.nih.gov/pubmed/36476607
http://dx.doi.org/10.1186/s40780-022-00262-x

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