Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification

[Image: see text] 6,7-Dehydroroyleanone (DHR) is a caspase-induced cytotoxic abietane diterpene, frequently found on Plectranthus spp. A pharmaceutical formulation consisting of a DHR-squalene conjugate was synthesized and analyzed by different techniques such as scanning electron microscopy (SEM)....

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Detalles Bibliográficos
Autores principales: García, Catarina, Bernardes, Carlos E. S., Piedade, M. Fátima M., Fumagalli, Gaia, Colombo, Eleonora, Díaz-Lanza, Ana M., Reis, Catarina P., Correia, Isabel, Ascensão, Lia, Passarella, Daniele, da Piedade, Manuel E. Minas, Rijo, Patrícia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730763/
https://www.ncbi.nlm.nih.gov/pubmed/36506152
http://dx.doi.org/10.1021/acsomega.2c05353
Descripción
Sumario:[Image: see text] 6,7-Dehydroroyleanone (DHR) is a caspase-induced cytotoxic abietane diterpene, frequently found on Plectranthus spp. A pharmaceutical formulation consisting of a DHR-squalene conjugate was synthesized and analyzed by different techniques such as scanning electron microscopy (SEM). The facile production of the dispersion of DHR-squalene conjugate nanoparticles in phosphate buffer (pH 7.4) suggests that this nanodelivery platform may be an effective system to improve the solubility and bioavailability of DHR, so that therapeutical systemic levels may be achieved.

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