Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification

[Image: see text] 6,7-Dehydroroyleanone (DHR) is a caspase-induced cytotoxic abietane diterpene, frequently found on Plectranthus spp. A pharmaceutical formulation consisting of a DHR-squalene conjugate was synthesized and analyzed by different techniques such as scanning electron microscopy (SEM)....

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Autores principales: García, Catarina, Bernardes, Carlos E. S., Piedade, M. Fátima M., Fumagalli, Gaia, Colombo, Eleonora, Díaz-Lanza, Ana M., Reis, Catarina P., Correia, Isabel, Ascensão, Lia, Passarella, Daniele, da Piedade, Manuel E. Minas, Rijo, Patrícia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730763/
https://www.ncbi.nlm.nih.gov/pubmed/36506152
http://dx.doi.org/10.1021/acsomega.2c05353
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author García, Catarina
Bernardes, Carlos E. S.
Piedade, M. Fátima M.
Fumagalli, Gaia
Colombo, Eleonora
Díaz-Lanza, Ana M.
Reis, Catarina P.
Correia, Isabel
Ascensão, Lia
Passarella, Daniele
da Piedade, Manuel E. Minas
Rijo, Patrícia
author_facet García, Catarina
Bernardes, Carlos E. S.
Piedade, M. Fátima M.
Fumagalli, Gaia
Colombo, Eleonora
Díaz-Lanza, Ana M.
Reis, Catarina P.
Correia, Isabel
Ascensão, Lia
Passarella, Daniele
da Piedade, Manuel E. Minas
Rijo, Patrícia
author_sort García, Catarina
collection PubMed
description [Image: see text] 6,7-Dehydroroyleanone (DHR) is a caspase-induced cytotoxic abietane diterpene, frequently found on Plectranthus spp. A pharmaceutical formulation consisting of a DHR-squalene conjugate was synthesized and analyzed by different techniques such as scanning electron microscopy (SEM). The facile production of the dispersion of DHR-squalene conjugate nanoparticles in phosphate buffer (pH 7.4) suggests that this nanodelivery platform may be an effective system to improve the solubility and bioavailability of DHR, so that therapeutical systemic levels may be achieved.
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spelling pubmed-97307632022-12-09 Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification García, Catarina Bernardes, Carlos E. S. Piedade, M. Fátima M. Fumagalli, Gaia Colombo, Eleonora Díaz-Lanza, Ana M. Reis, Catarina P. Correia, Isabel Ascensão, Lia Passarella, Daniele da Piedade, Manuel E. Minas Rijo, Patrícia ACS Omega [Image: see text] 6,7-Dehydroroyleanone (DHR) is a caspase-induced cytotoxic abietane diterpene, frequently found on Plectranthus spp. A pharmaceutical formulation consisting of a DHR-squalene conjugate was synthesized and analyzed by different techniques such as scanning electron microscopy (SEM). The facile production of the dispersion of DHR-squalene conjugate nanoparticles in phosphate buffer (pH 7.4) suggests that this nanodelivery platform may be an effective system to improve the solubility and bioavailability of DHR, so that therapeutical systemic levels may be achieved. American Chemical Society 2022-11-23 /pmc/articles/PMC9730763/ /pubmed/36506152 http://dx.doi.org/10.1021/acsomega.2c05353 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle García, Catarina
Bernardes, Carlos E. S.
Piedade, M. Fátima M.
Fumagalli, Gaia
Colombo, Eleonora
Díaz-Lanza, Ana M.
Reis, Catarina P.
Correia, Isabel
Ascensão, Lia
Passarella, Daniele
da Piedade, Manuel E. Minas
Rijo, Patrícia
Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification
title Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification
title_full Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification
title_fullStr Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification
title_full_unstemmed Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification
title_short Dehydroroyleanone as a Building Block for a Drug Delivery Platform Based on Self-Assembled Nanoparticles: Structural Studies and Chemical Modification
title_sort dehydroroyleanone as a building block for a drug delivery platform based on self-assembled nanoparticles: structural studies and chemical modification
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730763/
https://www.ncbi.nlm.nih.gov/pubmed/36506152
http://dx.doi.org/10.1021/acsomega.2c05353
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