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Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice

ADPKD has few therapeutic options. Tolvaptan slows disease but has side effects limiting its tolerability. Bempedoic acid (BA), an ATP citrate-lyase (ACLY) inhibitor FDA-approved for hypercholesterolemia, catalyzes a key step in fatty acid/sterol synthesis important for cell proliferation. BA is act...

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Detalles Bibliográficos
Autores principales:	Hallows, Kenneth R., Li, Hui, Saitta, Biagio, Sepehr, Saman, Huang, Polly, Pham, Jessica, Wang, Jonathan, Mancino, Valeria, Chung, Eun Ji, Pinkosky, Stephen L., Pastor-Soler, Núria M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730828/ https://www.ncbi.nlm.nih.gov/pubmed/36504724 http://dx.doi.org/10.3389/fmolb.2022.1001941

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