New-onset systemic lupus erythematosus presenting with pseudo-pseudo Meigs’ syndrome

Systemic lupus erythematosus is a complex disease and can present with almost any organ involvement, including serosal inflammation. Our patient is not known to have any medical problems, presented for the first time with pseudo-pseudo Meigs’ syndrome (PPMS), and after extensive workup to rule out other possibilities like infection and malignancy, she was found to have systemic lupus erythematosus. Several other cases have been reported in the literature; our patient had to have a pleural biopsy for completion of workup. She responded to prednisone and Immune suppression therapy (including mycophenolate mofetil (MMF) and Plaquenil).