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Growing concerns on male reproductive health amidst COVID-19 pandemic

Blood–testis barrier is body’s innate mechanism to defend germ cells by creating a physical and immunological barrier. But some viral infections are known to evade it. As ACE2 and TMPRSS2 are present all over the body including male reproductive tract, it is worth exploring how coronavirus disease (...

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Detalles Bibliográficos
Autores principales: Agrawal, Megha, Kumar, Vikas, Vardhan, Gyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731087/
https://www.ncbi.nlm.nih.gov/pubmed/36505593
http://dx.doi.org/10.4103/jfmpc.jfmpc_199_22
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author Agrawal, Megha
Kumar, Vikas
Vardhan, Gyan
author_facet Agrawal, Megha
Kumar, Vikas
Vardhan, Gyan
author_sort Agrawal, Megha
collection PubMed
description Blood–testis barrier is body’s innate mechanism to defend germ cells by creating a physical and immunological barrier. But some viral infections are known to evade it. As ACE2 and TMPRSS2 are present all over the body including male reproductive tract, it is worth exploring how coronavirus disease (COVID-19) could possibly affect male fertility. A review of literature was done using search engines like PubMed, Medline, Google Scholar, etc., and all the latest articles up to May 2021 were considered. Some studies have substantiated the presence of orchitis in COVID patients using semen and tissue samples. Though most studies report the absence of virus in testis, involvement of seminiferous tubules has been seen in pathological analysis suggesting defective spermatogenesis. This can be primarily attributed to inflammation and increased vascular permeability. Other factors that could affect male fertility are fever, autoimmune response, drugs, and erectile dysfunction. Male fertility is an important aspect of health care and must be looked into. Further studies can be done to understand host immunity towards SARS-CoV-2 in the testis. It will be worthwhile to know whether viral orchitis and its sequelae are acute or chronic in nature, and if they are reversible. Effect of the virus on female reproductive tract can also be assessed further. Counselling can be given to affected/recovering patients along with correct selection of drugs to prevent these long-term complications.
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spelling pubmed-97310872022-12-09 Growing concerns on male reproductive health amidst COVID-19 pandemic Agrawal, Megha Kumar, Vikas Vardhan, Gyan J Family Med Prim Care Review Article Blood–testis barrier is body’s innate mechanism to defend germ cells by creating a physical and immunological barrier. But some viral infections are known to evade it. As ACE2 and TMPRSS2 are present all over the body including male reproductive tract, it is worth exploring how coronavirus disease (COVID-19) could possibly affect male fertility. A review of literature was done using search engines like PubMed, Medline, Google Scholar, etc., and all the latest articles up to May 2021 were considered. Some studies have substantiated the presence of orchitis in COVID patients using semen and tissue samples. Though most studies report the absence of virus in testis, involvement of seminiferous tubules has been seen in pathological analysis suggesting defective spermatogenesis. This can be primarily attributed to inflammation and increased vascular permeability. Other factors that could affect male fertility are fever, autoimmune response, drugs, and erectile dysfunction. Male fertility is an important aspect of health care and must be looked into. Further studies can be done to understand host immunity towards SARS-CoV-2 in the testis. It will be worthwhile to know whether viral orchitis and its sequelae are acute or chronic in nature, and if they are reversible. Effect of the virus on female reproductive tract can also be assessed further. Counselling can be given to affected/recovering patients along with correct selection of drugs to prevent these long-term complications. Wolters Kluwer - Medknow 2022-09 2022-10-14 /pmc/articles/PMC9731087/ /pubmed/36505593 http://dx.doi.org/10.4103/jfmpc.jfmpc_199_22 Text en Copyright: © 2022 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Agrawal, Megha
Kumar, Vikas
Vardhan, Gyan
Growing concerns on male reproductive health amidst COVID-19 pandemic
title Growing concerns on male reproductive health amidst COVID-19 pandemic
title_full Growing concerns on male reproductive health amidst COVID-19 pandemic
title_fullStr Growing concerns on male reproductive health amidst COVID-19 pandemic
title_full_unstemmed Growing concerns on male reproductive health amidst COVID-19 pandemic
title_short Growing concerns on male reproductive health amidst COVID-19 pandemic
title_sort growing concerns on male reproductive health amidst covid-19 pandemic
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731087/
https://www.ncbi.nlm.nih.gov/pubmed/36505593
http://dx.doi.org/10.4103/jfmpc.jfmpc_199_22
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