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Higher baseline BMI and lower estimated median income is associated with increasing BMI after endometrial cancer diagnosis

INTRODUCTION: Endometrial cancer is often directly related to obesity and interventions for weight loss have mixed results. Risk factors for continued weight gain after diagnosis are not clearly defined in the literature. The objective of this study is to describe risk factors associated with increa...

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Autores principales: Petersen Harrington, Shariska, Balmaceda, Julia, Spoozak, Lori, Jewell, Andrea, Fitzgerald-Wolff, Sharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731388/
https://www.ncbi.nlm.nih.gov/pubmed/36506038
http://dx.doi.org/10.1016/j.gore.2022.101109
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author Petersen Harrington, Shariska
Balmaceda, Julia
Spoozak, Lori
Jewell, Andrea
Fitzgerald-Wolff, Sharon
author_facet Petersen Harrington, Shariska
Balmaceda, Julia
Spoozak, Lori
Jewell, Andrea
Fitzgerald-Wolff, Sharon
author_sort Petersen Harrington, Shariska
collection PubMed
description INTRODUCTION: Endometrial cancer is often directly related to obesity and interventions for weight loss have mixed results. Risk factors for continued weight gain after diagnosis are not clearly defined in the literature. The objective of this study is to describe risk factors associated with increased body mass index (BMI) trajectory among endometrial cancer patients. METHODS: Patients who were surgically treated for endometrial cancer at a single institution between 2010 and 2015 were identified. Demographics including age, race/ethnicity and estimated median income at diagnosis were obtained. BMI at five time points after diagnosis were calculated. BMI trajectories were estimated by latent class growth modeling using the PROC TRAJ procedure in SAS. Chi-squared tests and ANOVA were used to assess differences between trajectory groups. Statistical significance was set to a p-value < 0.05. RESULTS: Of 695 patients included in the study, the average age at diagnosis was 62 years and over 70% of patients were obese at baseline. Patients experienced increasing, stable, or decreasing BMI over 2 years following diagnosis. Patients with younger age and lower estimated median income were most likely to be in the increasing BMI group. Among obese patients, those with Class I obesity (BMI 30 to 34.9 kg/m(2)) were most likely to experience decreasing BMI and those with Class III obesity (BMI > 40 kg/m(2)) were most likely to experience increasing BMI, p < 0.0001. CONCLUSION: A third of endometrial cancer survivors experience increasing BMI. Severity of obesity at diagnosis matters, patients with severe obesity (Class III) were most likely to experience weight gain.
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spelling pubmed-97313882022-12-09 Higher baseline BMI and lower estimated median income is associated with increasing BMI after endometrial cancer diagnosis Petersen Harrington, Shariska Balmaceda, Julia Spoozak, Lori Jewell, Andrea Fitzgerald-Wolff, Sharon Gynecol Oncol Rep Research Report INTRODUCTION: Endometrial cancer is often directly related to obesity and interventions for weight loss have mixed results. Risk factors for continued weight gain after diagnosis are not clearly defined in the literature. The objective of this study is to describe risk factors associated with increased body mass index (BMI) trajectory among endometrial cancer patients. METHODS: Patients who were surgically treated for endometrial cancer at a single institution between 2010 and 2015 were identified. Demographics including age, race/ethnicity and estimated median income at diagnosis were obtained. BMI at five time points after diagnosis were calculated. BMI trajectories were estimated by latent class growth modeling using the PROC TRAJ procedure in SAS. Chi-squared tests and ANOVA were used to assess differences between trajectory groups. Statistical significance was set to a p-value < 0.05. RESULTS: Of 695 patients included in the study, the average age at diagnosis was 62 years and over 70% of patients were obese at baseline. Patients experienced increasing, stable, or decreasing BMI over 2 years following diagnosis. Patients with younger age and lower estimated median income were most likely to be in the increasing BMI group. Among obese patients, those with Class I obesity (BMI 30 to 34.9 kg/m(2)) were most likely to experience decreasing BMI and those with Class III obesity (BMI > 40 kg/m(2)) were most likely to experience increasing BMI, p < 0.0001. CONCLUSION: A third of endometrial cancer survivors experience increasing BMI. Severity of obesity at diagnosis matters, patients with severe obesity (Class III) were most likely to experience weight gain. Elsevier 2022-11-24 /pmc/articles/PMC9731388/ /pubmed/36506038 http://dx.doi.org/10.1016/j.gore.2022.101109 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Report
Petersen Harrington, Shariska
Balmaceda, Julia
Spoozak, Lori
Jewell, Andrea
Fitzgerald-Wolff, Sharon
Higher baseline BMI and lower estimated median income is associated with increasing BMI after endometrial cancer diagnosis
title Higher baseline BMI and lower estimated median income is associated with increasing BMI after endometrial cancer diagnosis
title_full Higher baseline BMI and lower estimated median income is associated with increasing BMI after endometrial cancer diagnosis
title_fullStr Higher baseline BMI and lower estimated median income is associated with increasing BMI after endometrial cancer diagnosis
title_full_unstemmed Higher baseline BMI and lower estimated median income is associated with increasing BMI after endometrial cancer diagnosis
title_short Higher baseline BMI and lower estimated median income is associated with increasing BMI after endometrial cancer diagnosis
title_sort higher baseline bmi and lower estimated median income is associated with increasing bmi after endometrial cancer diagnosis
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731388/
https://www.ncbi.nlm.nih.gov/pubmed/36506038
http://dx.doi.org/10.1016/j.gore.2022.101109
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