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Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis

BACKGROUND: Oral mucositis (OM) is a common side effect of chemotherapy and radiotherapy in patients with cancers. The prevention or treatment of OM in cancer patients is crucial in the treatment of cancer. METHODS: We searched PubMed, Embase, and Cochrane Library for the randomized control trials (...

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Autores principales: Peng, Tzu-Rong, Tsai, Fang-Pei, Wu, Ta-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731456/
https://www.ncbi.nlm.nih.gov/pubmed/36480513
http://dx.doi.org/10.1371/journal.pone.0278102
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author Peng, Tzu-Rong
Tsai, Fang-Pei
Wu, Ta-Wei
author_facet Peng, Tzu-Rong
Tsai, Fang-Pei
Wu, Ta-Wei
author_sort Peng, Tzu-Rong
collection PubMed
description BACKGROUND: Oral mucositis (OM) is a common side effect of chemotherapy and radiotherapy in patients with cancers. The prevention or treatment of OM in cancer patients is crucial in the treatment of cancer. METHODS: We searched PubMed, Embase, and Cochrane Library for the randomized control trials (RCTs) of interventions for preventing and treating OM. Network meta-analysis (NMA) was performed to estimate odds ratios (ORs) and 95% confidence intervals (CI) from both direct and indirect evidence. The prespecified primary efficacy outcome was the treatment effect of moderate to severe oral mucositis with 12 interventions. The outcome was moderate to a severe grade of OM. RESULTS: This study included 55 RCTs with 3,552 participants. The results showed that honey significantly lowered the risk of chemo/radiotherapy-induced moderate to severe oral mucositis than placebo (OR: 0.01, 95%CI 0.00 to 0.45), followed by lignocaine (OR: 0.07, 95%CI 0.00 to 0.95). The surface under cumulative ranking curve (SUCRA) values for honey were 0.95, followed by lignocaine (SUCRA, 0.81) and benzydamine (SUCRA, 0.78). CONCLUSIONS: The honey is effective for patients with cancer undergoing chemotherapy or radiotherapy-induced oral mucositis.
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spelling pubmed-97314562022-12-09 Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis Peng, Tzu-Rong Tsai, Fang-Pei Wu, Ta-Wei PLoS One Research Article BACKGROUND: Oral mucositis (OM) is a common side effect of chemotherapy and radiotherapy in patients with cancers. The prevention or treatment of OM in cancer patients is crucial in the treatment of cancer. METHODS: We searched PubMed, Embase, and Cochrane Library for the randomized control trials (RCTs) of interventions for preventing and treating OM. Network meta-analysis (NMA) was performed to estimate odds ratios (ORs) and 95% confidence intervals (CI) from both direct and indirect evidence. The prespecified primary efficacy outcome was the treatment effect of moderate to severe oral mucositis with 12 interventions. The outcome was moderate to a severe grade of OM. RESULTS: This study included 55 RCTs with 3,552 participants. The results showed that honey significantly lowered the risk of chemo/radiotherapy-induced moderate to severe oral mucositis than placebo (OR: 0.01, 95%CI 0.00 to 0.45), followed by lignocaine (OR: 0.07, 95%CI 0.00 to 0.95). The surface under cumulative ranking curve (SUCRA) values for honey were 0.95, followed by lignocaine (SUCRA, 0.81) and benzydamine (SUCRA, 0.78). CONCLUSIONS: The honey is effective for patients with cancer undergoing chemotherapy or radiotherapy-induced oral mucositis. Public Library of Science 2022-12-08 /pmc/articles/PMC9731456/ /pubmed/36480513 http://dx.doi.org/10.1371/journal.pone.0278102 Text en © 2022 Peng et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Peng, Tzu-Rong
Tsai, Fang-Pei
Wu, Ta-Wei
Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis
title Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis
title_full Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis
title_fullStr Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis
title_full_unstemmed Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis
title_short Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis
title_sort effects of various treatments for preventing oral mucositis in cancer patients: a network meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731456/
https://www.ncbi.nlm.nih.gov/pubmed/36480513
http://dx.doi.org/10.1371/journal.pone.0278102
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