Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins

The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the conserved tyrosine residues and recruitment of the tandem SH2 (Src homology 2) domain effector proteins, Syk and PI 3-kinase. We hav...

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Detalles Bibliográficos
Autores principales: Maqsood, Zahra, Clark, Joanne C., Martin, Eleyna M., Cheung, Yam Fung Hilaire, Morán, Luis A., Watson, Sean E. T., Pike, Jeremy A., Di, Ying, Poulter, Natalie S., Slater, Alexandre, Lange, Bodo M. H., Nieswandt, Bernhard, Eble, Johannes A., Tomlinson, Mike G., Owen, Dylan M., Stegner, David, Bridge, Lloyd J., Wierling, Christoph, Watson, Steve P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731471/
https://www.ncbi.nlm.nih.gov/pubmed/36441766
http://dx.doi.org/10.1371/journal.pcbi.1010708

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