TGFβ pathway is required for viable gestation of Fanconi anemia embryos

Overexpression of the TGFβ pathway impairs the proliferation of the hematopoietic stem and progenitor cells (HSPCs) pool in Fanconi anemia (FA). TGFβ promotes the expression of NHEJ genes, known to function in a low-fidelity DNA repair pathway, and pharmacological inhibition of TGFβ signaling rescue...

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Detalles Bibliográficos
Autores principales: Rodríguez, Alfredo, Epperly, Michael, Filiatrault, Jessica, Velázquez, Martha, Yang, Chunyu, McQueen, Kelsey, Sambel, Larissa A., Nguyen, Huy, Iyer, Divya Ramalingam, Juárez, Ulises, Ayala-Zambrano, Cecilia, Martignetti, David B., Frías, Sara, Fisher, Renee, Parmar, Kalindi, Greenberger, Joel S., D’Andrea, Alan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731498/
https://www.ncbi.nlm.nih.gov/pubmed/36441774
http://dx.doi.org/10.1371/journal.pgen.1010459

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