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Oscillations support short latency co-firing of neurons during human episodic memory formation
Theta and gamma oscillations in the medial temporal lobe are suggested to play a critical role for human memory formation via establishing synchrony in neural assemblies. Arguably, such synchrony facilitates efficient information transfer between neurons and enhances synaptic plasticity, both of whi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731574/ https://www.ncbi.nlm.nih.gov/pubmed/36448671 http://dx.doi.org/10.7554/eLife.78109 |
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author | Roux, Frédéric Parish, George Chelvarajah, Ramesh Rollings, David T Sawlani, Vijay Hamer, Hajo Gollwitzer, Stephanie Kreiselmeyer, Gernot ter Wal, Marije J Kolibius, Luca Staresina, Bernhard P Wimber, Maria Self, Matthew W Hanslmayr, Simon |
author_facet | Roux, Frédéric Parish, George Chelvarajah, Ramesh Rollings, David T Sawlani, Vijay Hamer, Hajo Gollwitzer, Stephanie Kreiselmeyer, Gernot ter Wal, Marije J Kolibius, Luca Staresina, Bernhard P Wimber, Maria Self, Matthew W Hanslmayr, Simon |
author_sort | Roux, Frédéric |
collection | PubMed |
description | Theta and gamma oscillations in the medial temporal lobe are suggested to play a critical role for human memory formation via establishing synchrony in neural assemblies. Arguably, such synchrony facilitates efficient information transfer between neurons and enhances synaptic plasticity, both of which benefit episodic memory formation. However, to date little evidence exists from humans that would provide direct evidence for such a specific role of theta and gamma oscillations for episodic memory formation. Here, we investigate how oscillations shape the temporal structure of neural firing during memory formation in the medial temporal lobe. We measured neural firing and local field potentials in human epilepsy patients via micro-wire electrode recordings to analyze whether brain oscillations are related to co-incidences of firing between neurons during successful and unsuccessful encoding of episodic memories. The results show that phase-coupling of neurons to faster theta and gamma oscillations correlates with co-firing at short latencies (~20–30 ms) and occurs during successful memory formation. Phase-coupling at slower oscillations in these same frequency bands, in contrast, correlates with longer co-firing latencies and occurs during memory failure. Thus, our findings suggest that neural oscillations play a role for the synchronization of neural firing in the medial temporal lobe during the encoding of episodic memories. |
format | Online Article Text |
id | pubmed-9731574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-97315742022-12-09 Oscillations support short latency co-firing of neurons during human episodic memory formation Roux, Frédéric Parish, George Chelvarajah, Ramesh Rollings, David T Sawlani, Vijay Hamer, Hajo Gollwitzer, Stephanie Kreiselmeyer, Gernot ter Wal, Marije J Kolibius, Luca Staresina, Bernhard P Wimber, Maria Self, Matthew W Hanslmayr, Simon eLife Neuroscience Theta and gamma oscillations in the medial temporal lobe are suggested to play a critical role for human memory formation via establishing synchrony in neural assemblies. Arguably, such synchrony facilitates efficient information transfer between neurons and enhances synaptic plasticity, both of which benefit episodic memory formation. However, to date little evidence exists from humans that would provide direct evidence for such a specific role of theta and gamma oscillations for episodic memory formation. Here, we investigate how oscillations shape the temporal structure of neural firing during memory formation in the medial temporal lobe. We measured neural firing and local field potentials in human epilepsy patients via micro-wire electrode recordings to analyze whether brain oscillations are related to co-incidences of firing between neurons during successful and unsuccessful encoding of episodic memories. The results show that phase-coupling of neurons to faster theta and gamma oscillations correlates with co-firing at short latencies (~20–30 ms) and occurs during successful memory formation. Phase-coupling at slower oscillations in these same frequency bands, in contrast, correlates with longer co-firing latencies and occurs during memory failure. Thus, our findings suggest that neural oscillations play a role for the synchronization of neural firing in the medial temporal lobe during the encoding of episodic memories. eLife Sciences Publications, Ltd 2022-11-30 /pmc/articles/PMC9731574/ /pubmed/36448671 http://dx.doi.org/10.7554/eLife.78109 Text en © 2022, Roux et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Roux, Frédéric Parish, George Chelvarajah, Ramesh Rollings, David T Sawlani, Vijay Hamer, Hajo Gollwitzer, Stephanie Kreiselmeyer, Gernot ter Wal, Marije J Kolibius, Luca Staresina, Bernhard P Wimber, Maria Self, Matthew W Hanslmayr, Simon Oscillations support short latency co-firing of neurons during human episodic memory formation |
title | Oscillations support short latency co-firing of neurons during human episodic memory formation |
title_full | Oscillations support short latency co-firing of neurons during human episodic memory formation |
title_fullStr | Oscillations support short latency co-firing of neurons during human episodic memory formation |
title_full_unstemmed | Oscillations support short latency co-firing of neurons during human episodic memory formation |
title_short | Oscillations support short latency co-firing of neurons during human episodic memory formation |
title_sort | oscillations support short latency co-firing of neurons during human episodic memory formation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731574/ https://www.ncbi.nlm.nih.gov/pubmed/36448671 http://dx.doi.org/10.7554/eLife.78109 |
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