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Oscillations support short latency co-firing of neurons during human episodic memory formation

Theta and gamma oscillations in the medial temporal lobe are suggested to play a critical role for human memory formation via establishing synchrony in neural assemblies. Arguably, such synchrony facilitates efficient information transfer between neurons and enhances synaptic plasticity, both of whi...

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Autores principales: Roux, Frédéric, Parish, George, Chelvarajah, Ramesh, Rollings, David T, Sawlani, Vijay, Hamer, Hajo, Gollwitzer, Stephanie, Kreiselmeyer, Gernot, ter Wal, Marije J, Kolibius, Luca, Staresina, Bernhard P, Wimber, Maria, Self, Matthew W, Hanslmayr, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731574/
https://www.ncbi.nlm.nih.gov/pubmed/36448671
http://dx.doi.org/10.7554/eLife.78109
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author Roux, Frédéric
Parish, George
Chelvarajah, Ramesh
Rollings, David T
Sawlani, Vijay
Hamer, Hajo
Gollwitzer, Stephanie
Kreiselmeyer, Gernot
ter Wal, Marije J
Kolibius, Luca
Staresina, Bernhard P
Wimber, Maria
Self, Matthew W
Hanslmayr, Simon
author_facet Roux, Frédéric
Parish, George
Chelvarajah, Ramesh
Rollings, David T
Sawlani, Vijay
Hamer, Hajo
Gollwitzer, Stephanie
Kreiselmeyer, Gernot
ter Wal, Marije J
Kolibius, Luca
Staresina, Bernhard P
Wimber, Maria
Self, Matthew W
Hanslmayr, Simon
author_sort Roux, Frédéric
collection PubMed
description Theta and gamma oscillations in the medial temporal lobe are suggested to play a critical role for human memory formation via establishing synchrony in neural assemblies. Arguably, such synchrony facilitates efficient information transfer between neurons and enhances synaptic plasticity, both of which benefit episodic memory formation. However, to date little evidence exists from humans that would provide direct evidence for such a specific role of theta and gamma oscillations for episodic memory formation. Here, we investigate how oscillations shape the temporal structure of neural firing during memory formation in the medial temporal lobe. We measured neural firing and local field potentials in human epilepsy patients via micro-wire electrode recordings to analyze whether brain oscillations are related to co-incidences of firing between neurons during successful and unsuccessful encoding of episodic memories. The results show that phase-coupling of neurons to faster theta and gamma oscillations correlates with co-firing at short latencies (~20–30 ms) and occurs during successful memory formation. Phase-coupling at slower oscillations in these same frequency bands, in contrast, correlates with longer co-firing latencies and occurs during memory failure. Thus, our findings suggest that neural oscillations play a role for the synchronization of neural firing in the medial temporal lobe during the encoding of episodic memories.
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spelling pubmed-97315742022-12-09 Oscillations support short latency co-firing of neurons during human episodic memory formation Roux, Frédéric Parish, George Chelvarajah, Ramesh Rollings, David T Sawlani, Vijay Hamer, Hajo Gollwitzer, Stephanie Kreiselmeyer, Gernot ter Wal, Marije J Kolibius, Luca Staresina, Bernhard P Wimber, Maria Self, Matthew W Hanslmayr, Simon eLife Neuroscience Theta and gamma oscillations in the medial temporal lobe are suggested to play a critical role for human memory formation via establishing synchrony in neural assemblies. Arguably, such synchrony facilitates efficient information transfer between neurons and enhances synaptic plasticity, both of which benefit episodic memory formation. However, to date little evidence exists from humans that would provide direct evidence for such a specific role of theta and gamma oscillations for episodic memory formation. Here, we investigate how oscillations shape the temporal structure of neural firing during memory formation in the medial temporal lobe. We measured neural firing and local field potentials in human epilepsy patients via micro-wire electrode recordings to analyze whether brain oscillations are related to co-incidences of firing between neurons during successful and unsuccessful encoding of episodic memories. The results show that phase-coupling of neurons to faster theta and gamma oscillations correlates with co-firing at short latencies (~20–30 ms) and occurs during successful memory formation. Phase-coupling at slower oscillations in these same frequency bands, in contrast, correlates with longer co-firing latencies and occurs during memory failure. Thus, our findings suggest that neural oscillations play a role for the synchronization of neural firing in the medial temporal lobe during the encoding of episodic memories. eLife Sciences Publications, Ltd 2022-11-30 /pmc/articles/PMC9731574/ /pubmed/36448671 http://dx.doi.org/10.7554/eLife.78109 Text en © 2022, Roux et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Roux, Frédéric
Parish, George
Chelvarajah, Ramesh
Rollings, David T
Sawlani, Vijay
Hamer, Hajo
Gollwitzer, Stephanie
Kreiselmeyer, Gernot
ter Wal, Marije J
Kolibius, Luca
Staresina, Bernhard P
Wimber, Maria
Self, Matthew W
Hanslmayr, Simon
Oscillations support short latency co-firing of neurons during human episodic memory formation
title Oscillations support short latency co-firing of neurons during human episodic memory formation
title_full Oscillations support short latency co-firing of neurons during human episodic memory formation
title_fullStr Oscillations support short latency co-firing of neurons during human episodic memory formation
title_full_unstemmed Oscillations support short latency co-firing of neurons during human episodic memory formation
title_short Oscillations support short latency co-firing of neurons during human episodic memory formation
title_sort oscillations support short latency co-firing of neurons during human episodic memory formation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731574/
https://www.ncbi.nlm.nih.gov/pubmed/36448671
http://dx.doi.org/10.7554/eLife.78109
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