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Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect
The study was mainly to evaluate the changes of left ventricular (LV) myocardial work (MW) in children with CKD stage 5 within 3 months after kidney transplantation (KTx). Forty‐three successful KTx recipients (mean age 10.6 years, 58% male) in childhood and 28 healthy children were enrolled. Genera...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731598/ https://www.ncbi.nlm.nih.gov/pubmed/36367189 http://dx.doi.org/10.1111/jch.14595 |
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author | Xiao, Fei Fan, Rui Zhang, Jingwei Ye, Min Li, Wei Liu, Donghong Liu, Longshan Yao, Fengjuan Lin, Hong Li, Cuiling |
author_facet | Xiao, Fei Fan, Rui Zhang, Jingwei Ye, Min Li, Wei Liu, Donghong Liu, Longshan Yao, Fengjuan Lin, Hong Li, Cuiling |
author_sort | Xiao, Fei |
collection | PubMed |
description | The study was mainly to evaluate the changes of left ventricular (LV) myocardial work (MW) in children with CKD stage 5 within 3 months after kidney transplantation (KTx). Forty‐three successful KTx recipients (mean age 10.6 years, 58% male) in childhood and 28 healthy children were enrolled. General clinical characteristics and laboratory parameters were collected. Cardiac structure, function, and LV MW were assessed by echocardiography before and after KTx. The results showed that significantly improvement was observed in LV global MW index (GWI), constructive MW (GCW), and wasted MW (GWW) (p < .01), but not in MW efficiency (GWE) and global longitudinal strain (GLS) (p > .05). Besides, blood pressure (BP), renal graft function, LV ejection fraction (LVEF), and LV mass index (LVMi) had obviously improved after KTx (p < .05). Nevertheless, compared with healthy children, higher BP, LVMi, GWW, more deteriorated LV diastolic function and lower GWE were still observed in patients after KTx. The ratio of dialysis duration to CKD course were negatively correlated with the improvements of GWE (p = .004), GWI (p = .01), and GCW (p = .01). In conclusion, a portion of LV MW parameters were obviously improved in children received KTx. Thus, LV MW was superior to GLS in evaluating LV systolic function recovery in these patients. Those patients with insignificant MW improvement should be closely monitored, and adjusted the treatment strategies timely to avoid serious and irreversible myocardial injury after KTx. |
format | Online Article Text |
id | pubmed-9731598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97315982022-12-12 Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect Xiao, Fei Fan, Rui Zhang, Jingwei Ye, Min Li, Wei Liu, Donghong Liu, Longshan Yao, Fengjuan Lin, Hong Li, Cuiling J Clin Hypertens (Greenwich) Myocardial Work The study was mainly to evaluate the changes of left ventricular (LV) myocardial work (MW) in children with CKD stage 5 within 3 months after kidney transplantation (KTx). Forty‐three successful KTx recipients (mean age 10.6 years, 58% male) in childhood and 28 healthy children were enrolled. General clinical characteristics and laboratory parameters were collected. Cardiac structure, function, and LV MW were assessed by echocardiography before and after KTx. The results showed that significantly improvement was observed in LV global MW index (GWI), constructive MW (GCW), and wasted MW (GWW) (p < .01), but not in MW efficiency (GWE) and global longitudinal strain (GLS) (p > .05). Besides, blood pressure (BP), renal graft function, LV ejection fraction (LVEF), and LV mass index (LVMi) had obviously improved after KTx (p < .05). Nevertheless, compared with healthy children, higher BP, LVMi, GWW, more deteriorated LV diastolic function and lower GWE were still observed in patients after KTx. The ratio of dialysis duration to CKD course were negatively correlated with the improvements of GWE (p = .004), GWI (p = .01), and GCW (p = .01). In conclusion, a portion of LV MW parameters were obviously improved in children received KTx. Thus, LV MW was superior to GLS in evaluating LV systolic function recovery in these patients. Those patients with insignificant MW improvement should be closely monitored, and adjusted the treatment strategies timely to avoid serious and irreversible myocardial injury after KTx. John Wiley and Sons Inc. 2022-11-11 /pmc/articles/PMC9731598/ /pubmed/36367189 http://dx.doi.org/10.1111/jch.14595 Text en © 2022 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Myocardial Work Xiao, Fei Fan, Rui Zhang, Jingwei Ye, Min Li, Wei Liu, Donghong Liu, Longshan Yao, Fengjuan Lin, Hong Li, Cuiling Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect |
title | Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect |
title_full | Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect |
title_fullStr | Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect |
title_full_unstemmed | Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect |
title_short | Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect |
title_sort | changes in myocardial work associated with pediatric kidney transplantation: a pilot study of short‐term postoperative effect |
topic | Myocardial Work |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731598/ https://www.ncbi.nlm.nih.gov/pubmed/36367189 http://dx.doi.org/10.1111/jch.14595 |
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