Cargando…

Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect

The study was mainly to evaluate the changes of left ventricular (LV) myocardial work (MW) in children with CKD stage 5 within 3 months after kidney transplantation (KTx). Forty‐three successful KTx recipients (mean age 10.6 years, 58% male) in childhood and 28 healthy children were enrolled. Genera...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Fei, Fan, Rui, Zhang, Jingwei, Ye, Min, Li, Wei, Liu, Donghong, Liu, Longshan, Yao, Fengjuan, Lin, Hong, Li, Cuiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731598/
https://www.ncbi.nlm.nih.gov/pubmed/36367189
http://dx.doi.org/10.1111/jch.14595
_version_ 1784845939894124544
author Xiao, Fei
Fan, Rui
Zhang, Jingwei
Ye, Min
Li, Wei
Liu, Donghong
Liu, Longshan
Yao, Fengjuan
Lin, Hong
Li, Cuiling
author_facet Xiao, Fei
Fan, Rui
Zhang, Jingwei
Ye, Min
Li, Wei
Liu, Donghong
Liu, Longshan
Yao, Fengjuan
Lin, Hong
Li, Cuiling
author_sort Xiao, Fei
collection PubMed
description The study was mainly to evaluate the changes of left ventricular (LV) myocardial work (MW) in children with CKD stage 5 within 3 months after kidney transplantation (KTx). Forty‐three successful KTx recipients (mean age 10.6 years, 58% male) in childhood and 28 healthy children were enrolled. General clinical characteristics and laboratory parameters were collected. Cardiac structure, function, and LV MW were assessed by echocardiography before and after KTx. The results showed that significantly improvement was observed in LV global MW index (GWI), constructive MW (GCW), and wasted MW (GWW) (p < .01), but not in MW efficiency (GWE) and global longitudinal strain (GLS) (p > .05). Besides, blood pressure (BP), renal graft function, LV ejection fraction (LVEF), and LV mass index (LVMi) had obviously improved after KTx (p < .05). Nevertheless, compared with healthy children, higher BP, LVMi, GWW, more deteriorated LV diastolic function and lower GWE were still observed in patients after KTx. The ratio of dialysis duration to CKD course were negatively correlated with the improvements of GWE (p = .004), GWI (p = .01), and GCW (p = .01). In conclusion, a portion of LV MW parameters were obviously improved in children received KTx. Thus, LV MW was superior to GLS in evaluating LV systolic function recovery in these patients. Those patients with insignificant MW improvement should be closely monitored, and adjusted the treatment strategies timely to avoid serious and irreversible myocardial injury after KTx.
format Online
Article
Text
id pubmed-9731598
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-97315982022-12-12 Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect Xiao, Fei Fan, Rui Zhang, Jingwei Ye, Min Li, Wei Liu, Donghong Liu, Longshan Yao, Fengjuan Lin, Hong Li, Cuiling J Clin Hypertens (Greenwich) Myocardial Work The study was mainly to evaluate the changes of left ventricular (LV) myocardial work (MW) in children with CKD stage 5 within 3 months after kidney transplantation (KTx). Forty‐three successful KTx recipients (mean age 10.6 years, 58% male) in childhood and 28 healthy children were enrolled. General clinical characteristics and laboratory parameters were collected. Cardiac structure, function, and LV MW were assessed by echocardiography before and after KTx. The results showed that significantly improvement was observed in LV global MW index (GWI), constructive MW (GCW), and wasted MW (GWW) (p < .01), but not in MW efficiency (GWE) and global longitudinal strain (GLS) (p > .05). Besides, blood pressure (BP), renal graft function, LV ejection fraction (LVEF), and LV mass index (LVMi) had obviously improved after KTx (p < .05). Nevertheless, compared with healthy children, higher BP, LVMi, GWW, more deteriorated LV diastolic function and lower GWE were still observed in patients after KTx. The ratio of dialysis duration to CKD course were negatively correlated with the improvements of GWE (p = .004), GWI (p = .01), and GCW (p = .01). In conclusion, a portion of LV MW parameters were obviously improved in children received KTx. Thus, LV MW was superior to GLS in evaluating LV systolic function recovery in these patients. Those patients with insignificant MW improvement should be closely monitored, and adjusted the treatment strategies timely to avoid serious and irreversible myocardial injury after KTx. John Wiley and Sons Inc. 2022-11-11 /pmc/articles/PMC9731598/ /pubmed/36367189 http://dx.doi.org/10.1111/jch.14595 Text en © 2022 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Myocardial Work
Xiao, Fei
Fan, Rui
Zhang, Jingwei
Ye, Min
Li, Wei
Liu, Donghong
Liu, Longshan
Yao, Fengjuan
Lin, Hong
Li, Cuiling
Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect
title Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect
title_full Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect
title_fullStr Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect
title_full_unstemmed Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect
title_short Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short‐term postoperative effect
title_sort changes in myocardial work associated with pediatric kidney transplantation: a pilot study of short‐term postoperative effect
topic Myocardial Work
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731598/
https://www.ncbi.nlm.nih.gov/pubmed/36367189
http://dx.doi.org/10.1111/jch.14595
work_keys_str_mv AT xiaofei changesinmyocardialworkassociatedwithpediatrickidneytransplantationapilotstudyofshorttermpostoperativeeffect
AT fanrui changesinmyocardialworkassociatedwithpediatrickidneytransplantationapilotstudyofshorttermpostoperativeeffect
AT zhangjingwei changesinmyocardialworkassociatedwithpediatrickidneytransplantationapilotstudyofshorttermpostoperativeeffect
AT yemin changesinmyocardialworkassociatedwithpediatrickidneytransplantationapilotstudyofshorttermpostoperativeeffect
AT liwei changesinmyocardialworkassociatedwithpediatrickidneytransplantationapilotstudyofshorttermpostoperativeeffect
AT liudonghong changesinmyocardialworkassociatedwithpediatrickidneytransplantationapilotstudyofshorttermpostoperativeeffect
AT liulongshan changesinmyocardialworkassociatedwithpediatrickidneytransplantationapilotstudyofshorttermpostoperativeeffect
AT yaofengjuan changesinmyocardialworkassociatedwithpediatrickidneytransplantationapilotstudyofshorttermpostoperativeeffect
AT linhong changesinmyocardialworkassociatedwithpediatrickidneytransplantationapilotstudyofshorttermpostoperativeeffect
AT licuiling changesinmyocardialworkassociatedwithpediatrickidneytransplantationapilotstudyofshorttermpostoperativeeffect