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Gut microbiota in hypertensive patients with versus without obstructive sleep apnea
We investigated the alteration of gut microbiota and the associated metabolic risks in hypertensive patients with obstructive sleep apnea (OSA) comorbidity. Fecal and blood samples were collected from 52 hypertensive patients, who were divided into three groups: A (controls, apnea‐hypopnea index[AHI...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731600/ https://www.ncbi.nlm.nih.gov/pubmed/36411588 http://dx.doi.org/10.1111/jch.14598 |
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author | Lu, Dasheng Xu, Shaodong Dai, Ping Wu, Lijuan Zhang, Hongxiang Zhou, Birong |
author_facet | Lu, Dasheng Xu, Shaodong Dai, Ping Wu, Lijuan Zhang, Hongxiang Zhou, Birong |
author_sort | Lu, Dasheng |
collection | PubMed |
description | We investigated the alteration of gut microbiota and the associated metabolic risks in hypertensive patients with obstructive sleep apnea (OSA) comorbidity. Fecal and blood samples were collected from 52 hypertensive patients, who were divided into three groups: A (controls, apnea‐hypopnea index[AHI] < 5, n = 15), B (mild OSA, 5 < AHI < 20, n = 17), and C (moderate‐to‐severe OSA, AHI > 20, n = 20). The composition of the gut microbiota was studied through 16s RNA sequencing of variable regions 3–4. Analysis of the results revealed that group C had a significant higher concentration of total cholesterol, low‐density lipoprotein, and IL‐1β compared with group A. The Shannon index showed that bacterial biodiversity was lower in OSA patients. At the phylum level, the ratio of Firmicutes to Bacteroidetes (F/B) was significantly higher in group C than in groups A and B. At the genus level, the relative abundance of short‐chain fatty acids (SCFA)‐producing bacteria (e.g., Bacteroides and Prevotella) was lower while the number of inflammation‐related bacteria (e.g., Lactobacillus) was increased in patients with OSA. We found that the IL‐1β level was negatively correlated with Bacteroidetes. The area under the receiver operating characteristic curve was .672 for F/B ratio in determining hypertensive patients with OSA. In patients with hypertension, OSA was associated with worse gut dysbiosis, as evidenced by decreased levels of short‐chain fatty acids‐producing bacteria and increased number of inflammation‐related bacteria. The differences in gut microbiota discriminate hypertensive patients with OSA from those without and may result in an enhanced inflammatory response and increase the risk of metabolic diseases. |
format | Online Article Text |
id | pubmed-9731600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97316002022-12-12 Gut microbiota in hypertensive patients with versus without obstructive sleep apnea Lu, Dasheng Xu, Shaodong Dai, Ping Wu, Lijuan Zhang, Hongxiang Zhou, Birong J Clin Hypertens (Greenwich) Gut Microbiota We investigated the alteration of gut microbiota and the associated metabolic risks in hypertensive patients with obstructive sleep apnea (OSA) comorbidity. Fecal and blood samples were collected from 52 hypertensive patients, who were divided into three groups: A (controls, apnea‐hypopnea index[AHI] < 5, n = 15), B (mild OSA, 5 < AHI < 20, n = 17), and C (moderate‐to‐severe OSA, AHI > 20, n = 20). The composition of the gut microbiota was studied through 16s RNA sequencing of variable regions 3–4. Analysis of the results revealed that group C had a significant higher concentration of total cholesterol, low‐density lipoprotein, and IL‐1β compared with group A. The Shannon index showed that bacterial biodiversity was lower in OSA patients. At the phylum level, the ratio of Firmicutes to Bacteroidetes (F/B) was significantly higher in group C than in groups A and B. At the genus level, the relative abundance of short‐chain fatty acids (SCFA)‐producing bacteria (e.g., Bacteroides and Prevotella) was lower while the number of inflammation‐related bacteria (e.g., Lactobacillus) was increased in patients with OSA. We found that the IL‐1β level was negatively correlated with Bacteroidetes. The area under the receiver operating characteristic curve was .672 for F/B ratio in determining hypertensive patients with OSA. In patients with hypertension, OSA was associated with worse gut dysbiosis, as evidenced by decreased levels of short‐chain fatty acids‐producing bacteria and increased number of inflammation‐related bacteria. The differences in gut microbiota discriminate hypertensive patients with OSA from those without and may result in an enhanced inflammatory response and increase the risk of metabolic diseases. John Wiley and Sons Inc. 2022-11-21 /pmc/articles/PMC9731600/ /pubmed/36411588 http://dx.doi.org/10.1111/jch.14598 Text en © 2022 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Gut Microbiota Lu, Dasheng Xu, Shaodong Dai, Ping Wu, Lijuan Zhang, Hongxiang Zhou, Birong Gut microbiota in hypertensive patients with versus without obstructive sleep apnea |
title | Gut microbiota in hypertensive patients with versus without obstructive sleep apnea |
title_full | Gut microbiota in hypertensive patients with versus without obstructive sleep apnea |
title_fullStr | Gut microbiota in hypertensive patients with versus without obstructive sleep apnea |
title_full_unstemmed | Gut microbiota in hypertensive patients with versus without obstructive sleep apnea |
title_short | Gut microbiota in hypertensive patients with versus without obstructive sleep apnea |
title_sort | gut microbiota in hypertensive patients with versus without obstructive sleep apnea |
topic | Gut Microbiota |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731600/ https://www.ncbi.nlm.nih.gov/pubmed/36411588 http://dx.doi.org/10.1111/jch.14598 |
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