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Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022)

Type 2 Diabetes In article number 2202342, Ronald J. Parchem and co‐workers describe two hIAPP protofibril‐specific antibodies which prevent β cell toxicity in type 2 diabetes (T2D). Treatment with mAbs increases survival in a mouse model of severe T2D, and pancreatic islets from treated mice show d...

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Autores principales: Bortoletto, Angelina S., Graham, W. Vallen, Trout, Gabriella, Bonito‐Oliva, Alessandra, Kazmi, Manija A., Gong, Jing, Weyburne, Emily, Houser, Brandy L., Sakmar, Thomas P., Parchem, Ronald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731679/
http://dx.doi.org/10.1002/advs.202270217
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author Bortoletto, Angelina S.
Graham, W. Vallen
Trout, Gabriella
Bonito‐Oliva, Alessandra
Kazmi, Manija A.
Gong, Jing
Weyburne, Emily
Houser, Brandy L.
Sakmar, Thomas P.
Parchem, Ronald J.
author_facet Bortoletto, Angelina S.
Graham, W. Vallen
Trout, Gabriella
Bonito‐Oliva, Alessandra
Kazmi, Manija A.
Gong, Jing
Weyburne, Emily
Houser, Brandy L.
Sakmar, Thomas P.
Parchem, Ronald J.
author_sort Bortoletto, Angelina S.
collection PubMed
description Type 2 Diabetes In article number 2202342, Ronald J. Parchem and co‐workers describe two hIAPP protofibril‐specific antibodies which prevent β cell toxicity in type 2 diabetes (T2D). Treatment with mAbs increases survival in a mouse model of severe T2D, and pancreatic islets from treated mice show decreased β cell death and macrophage infiltration, comparable to healthy wild‐type animals, as depicted in the photo. [Image: see text]
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spelling pubmed-97316792022-12-12 Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022) Bortoletto, Angelina S. Graham, W. Vallen Trout, Gabriella Bonito‐Oliva, Alessandra Kazmi, Manija A. Gong, Jing Weyburne, Emily Houser, Brandy L. Sakmar, Thomas P. Parchem, Ronald J. Adv Sci (Weinh) Frontispiece Type 2 Diabetes In article number 2202342, Ronald J. Parchem and co‐workers describe two hIAPP protofibril‐specific antibodies which prevent β cell toxicity in type 2 diabetes (T2D). Treatment with mAbs increases survival in a mouse model of severe T2D, and pancreatic islets from treated mice show decreased β cell death and macrophage infiltration, comparable to healthy wild‐type animals, as depicted in the photo. [Image: see text] John Wiley and Sons Inc. 2022-12-08 /pmc/articles/PMC9731679/ http://dx.doi.org/10.1002/advs.202270217 Text en © 2022 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Frontispiece
Bortoletto, Angelina S.
Graham, W. Vallen
Trout, Gabriella
Bonito‐Oliva, Alessandra
Kazmi, Manija A.
Gong, Jing
Weyburne, Emily
Houser, Brandy L.
Sakmar, Thomas P.
Parchem, Ronald J.
Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022)
title Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022)
title_full Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022)
title_fullStr Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022)
title_full_unstemmed Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022)
title_short Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022)
title_sort human islet amyloid polypeptide (hiapp) protofibril‐specific antibodies for detection and treatment of type 2 diabetes (adv. sci. 34/2022)
topic Frontispiece
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731679/
http://dx.doi.org/10.1002/advs.202270217
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