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Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022)
Type 2 Diabetes In article number 2202342, Ronald J. Parchem and co‐workers describe two hIAPP protofibril‐specific antibodies which prevent β cell toxicity in type 2 diabetes (T2D). Treatment with mAbs increases survival in a mouse model of severe T2D, and pancreatic islets from treated mice show d...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731679/ http://dx.doi.org/10.1002/advs.202270217 |
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author | Bortoletto, Angelina S. Graham, W. Vallen Trout, Gabriella Bonito‐Oliva, Alessandra Kazmi, Manija A. Gong, Jing Weyburne, Emily Houser, Brandy L. Sakmar, Thomas P. Parchem, Ronald J. |
author_facet | Bortoletto, Angelina S. Graham, W. Vallen Trout, Gabriella Bonito‐Oliva, Alessandra Kazmi, Manija A. Gong, Jing Weyburne, Emily Houser, Brandy L. Sakmar, Thomas P. Parchem, Ronald J. |
author_sort | Bortoletto, Angelina S. |
collection | PubMed |
description | Type 2 Diabetes In article number 2202342, Ronald J. Parchem and co‐workers describe two hIAPP protofibril‐specific antibodies which prevent β cell toxicity in type 2 diabetes (T2D). Treatment with mAbs increases survival in a mouse model of severe T2D, and pancreatic islets from treated mice show decreased β cell death and macrophage infiltration, comparable to healthy wild‐type animals, as depicted in the photo. [Image: see text] |
format | Online Article Text |
id | pubmed-9731679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97316792022-12-12 Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022) Bortoletto, Angelina S. Graham, W. Vallen Trout, Gabriella Bonito‐Oliva, Alessandra Kazmi, Manija A. Gong, Jing Weyburne, Emily Houser, Brandy L. Sakmar, Thomas P. Parchem, Ronald J. Adv Sci (Weinh) Frontispiece Type 2 Diabetes In article number 2202342, Ronald J. Parchem and co‐workers describe two hIAPP protofibril‐specific antibodies which prevent β cell toxicity in type 2 diabetes (T2D). Treatment with mAbs increases survival in a mouse model of severe T2D, and pancreatic islets from treated mice show decreased β cell death and macrophage infiltration, comparable to healthy wild‐type animals, as depicted in the photo. [Image: see text] John Wiley and Sons Inc. 2022-12-08 /pmc/articles/PMC9731679/ http://dx.doi.org/10.1002/advs.202270217 Text en © 2022 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Frontispiece Bortoletto, Angelina S. Graham, W. Vallen Trout, Gabriella Bonito‐Oliva, Alessandra Kazmi, Manija A. Gong, Jing Weyburne, Emily Houser, Brandy L. Sakmar, Thomas P. Parchem, Ronald J. Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022) |
title | Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022) |
title_full | Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022) |
title_fullStr | Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022) |
title_full_unstemmed | Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022) |
title_short | Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes (Adv. Sci. 34/2022) |
title_sort | human islet amyloid polypeptide (hiapp) protofibril‐specific antibodies for detection and treatment of type 2 diabetes (adv. sci. 34/2022) |
topic | Frontispiece |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731679/ http://dx.doi.org/10.1002/advs.202270217 |
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