Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease” (Adv. Sci. 34/2022)

Neurovasculature‐On‐A‐Chip In article number 2201882, Minjeong Jang, Nakwon Choi, and Hong Nam Kim present a hyperglycemic neurovascular unit‐on‐a‐chip model that can recapitulate the pathologies of diabetes‐induced Alzheimers' disease. The neurovascular pathologies are mediated by SIRT1 and th...

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Detalles Bibliográficos
Autores principales: Jang, Minjeong, Choi, Nakwon, Kim, Hong Nam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Inside Back Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731707/
http://dx.doi.org/10.1002/advs.202270219
Descripción
Sumario:Neurovasculature‐On‐A‐Chip In article number 2201882, Minjeong Jang, Nakwon Choi, and Hong Nam Kim present a hyperglycemic neurovascular unit‐on‐a‐chip model that can recapitulate the pathologies of diabetes‐induced Alzheimers' disease. The neurovascular pathologies are mediated by SIRT1 and thus could be rescued by the modulation of SIRT1 levels in each neuron and brain endothelial cell. [Image: see text]

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