Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease” (Adv. Sci. 34/2022)

Neurovasculature‐On‐A‐Chip In article number 2201882, Minjeong Jang, Nakwon Choi, and Hong Nam Kim present a hyperglycemic neurovascular unit‐on‐a‐chip model that can recapitulate the pathologies of diabetes‐induced Alzheimers' disease. The neurovascular pathologies are mediated by SIRT1 and th...

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Detalles Bibliográficos
Autores principales: Jang, Minjeong, Choi, Nakwon, Kim, Hong Nam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Inside Back Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731707/
http://dx.doi.org/10.1002/advs.202270219
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author Jang, Minjeong
Choi, Nakwon
Kim, Hong Nam
author_facet Jang, Minjeong
Choi, Nakwon
Kim, Hong Nam
author_sort Jang, Minjeong
collection PubMed
description Neurovasculature‐On‐A‐Chip In article number 2201882, Minjeong Jang, Nakwon Choi, and Hong Nam Kim present a hyperglycemic neurovascular unit‐on‐a‐chip model that can recapitulate the pathologies of diabetes‐induced Alzheimers' disease. The neurovascular pathologies are mediated by SIRT1 and thus could be rescued by the modulation of SIRT1 levels in each neuron and brain endothelial cell. [Image: see text]
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spelling pubmed-97317072022-12-12 Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease” (Adv. Sci. 34/2022) Jang, Minjeong Choi, Nakwon Kim, Hong Nam Adv Sci (Weinh) Inside Back Cover Neurovasculature‐On‐A‐Chip In article number 2201882, Minjeong Jang, Nakwon Choi, and Hong Nam Kim present a hyperglycemic neurovascular unit‐on‐a‐chip model that can recapitulate the pathologies of diabetes‐induced Alzheimers' disease. The neurovascular pathologies are mediated by SIRT1 and thus could be rescued by the modulation of SIRT1 levels in each neuron and brain endothelial cell. [Image: see text] John Wiley and Sons Inc. 2022-12-08 /pmc/articles/PMC9731707/ http://dx.doi.org/10.1002/advs.202270219 Text en © 2022 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Inside Back Cover
Jang, Minjeong
Choi, Nakwon
Kim, Hong Nam
Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease” (Adv. Sci. 34/2022)
title Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease” (Adv. Sci. 34/2022)
title_full Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease” (Adv. Sci. 34/2022)
title_fullStr Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease” (Adv. Sci. 34/2022)
title_full_unstemmed Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease” (Adv. Sci. 34/2022)
title_short Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease” (Adv. Sci. 34/2022)
title_sort hyperglycemic neurovasculature‐on‐a‐chip to study the effect of sirt1‐targeted therapy for the type 3 diabetes “alzheimer's disease” (adv. sci. 34/2022)
topic Inside Back Cover
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731707/
http://dx.doi.org/10.1002/advs.202270219
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