Genome‐Wide CRISPR/Cas9 Library Screening Revealed Dietary Restriction of Glutamine in Combination with Inhibition of Pyruvate Metabolism as Effective Liver Cancer Treatment

Hepatocellular carcinoma (HCC) is the second most lethal cancer worldwide. Glutamine is an essential, extracellular nutrient which supports HCC growth. Dietary glutamine deficiency may be a potential therapeutic approach for HCC. HCC cells overcome metabolic challenges by rewiring their metabolic pa...

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Detalles Bibliográficos
Autores principales: Yang, Chunxue, Lee, Derek, Zhang, Misty Shuo, Tse, Aki Pui‐Wah, Wei, Lai, Bao, Macus Hao‐Ran, Wong, Bowie Po‐Yee, Chan, Cerise Yuen‐Ki, Yuen, Vincent Wai‐Hin, Chen, Yiling, Wong, Carmen Chak‐Lui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731711/
https://www.ncbi.nlm.nih.gov/pubmed/36310121
http://dx.doi.org/10.1002/advs.202202104

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