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Eosinophilic esophagitis: Comparison of clinical, endoscopic and histological scoring systems

Background Eosinophilic Esophagitis (EoE) has received increasing attention as a disease entity, and it is now recognized as an important disorder of the Upper Gastrointestinal Tract. Topical corticosteroids (tCS) are effective in clinical-pathological remission induction (RI) and remission maintena...

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Autores principales: Lorenz, Nikolas Johannes, Link, Alexander, Czapiewski, Piotr, Arnim, Ulrike von
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731786/
https://www.ncbi.nlm.nih.gov/pubmed/36417921
http://dx.doi.org/10.1055/a-1855-1974
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author Lorenz, Nikolas Johannes
Link, Alexander
Czapiewski, Piotr
Arnim, Ulrike von
author_facet Lorenz, Nikolas Johannes
Link, Alexander
Czapiewski, Piotr
Arnim, Ulrike von
author_sort Lorenz, Nikolas Johannes
collection PubMed
description Background Eosinophilic Esophagitis (EoE) has received increasing attention as a disease entity, and it is now recognized as an important disorder of the Upper Gastrointestinal Tract. Topical corticosteroids (tCS) are effective in clinical-pathological remission induction (RI) and remission maintenance (RM) of active EoE. With scoring systems, such as clinical (SDI), endoscopic (EREFS), and histological (EoEHSS) systems, EoE can be graded, and its disease activity can be assessed. Objective To discover how closely results within each of the three scoring systems SDI, EREFS, and EoEHSS are correlated between initial diagnosis (ID), RI, and RM, and to determine how well scores from the three systems are intercorrelated at each time point. Methods Retrospective cohort analysis of patients with active EoE was performed between 2006 and 2020, with follow-up for up to 6 years. SDI, EREFS and EoEHSS scores were recorded at ID, at RI, and in RM. Evaluation employed descriptive statistics, the Friedman test, and Bonferroni-corrected post hoc pairwise comparisons. Results At RI 29 and at RM 19 EoE patients provided data. Significant correlations were found between EREFS and EoEHSS at RI and in RM. Pairwise comparisons showed significant differences between ID and RI for SDI, for EREFS, and for EoEHSS. Conclusion The scoring systems tested did not show intercorrelation at ID. Comparison revealed significant differences for SDI, EREFS, and EoEHSS between the systems at ID und RI, but not in RM, during tCS treatment. These results underline the efficacy of tCS (at RI and RM) in the treatment of active EoE.
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spelling pubmed-97317862022-12-09 Eosinophilic esophagitis: Comparison of clinical, endoscopic and histological scoring systems Lorenz, Nikolas Johannes Link, Alexander Czapiewski, Piotr Arnim, Ulrike von Z Gastroenterol Background Eosinophilic Esophagitis (EoE) has received increasing attention as a disease entity, and it is now recognized as an important disorder of the Upper Gastrointestinal Tract. Topical corticosteroids (tCS) are effective in clinical-pathological remission induction (RI) and remission maintenance (RM) of active EoE. With scoring systems, such as clinical (SDI), endoscopic (EREFS), and histological (EoEHSS) systems, EoE can be graded, and its disease activity can be assessed. Objective To discover how closely results within each of the three scoring systems SDI, EREFS, and EoEHSS are correlated between initial diagnosis (ID), RI, and RM, and to determine how well scores from the three systems are intercorrelated at each time point. Methods Retrospective cohort analysis of patients with active EoE was performed between 2006 and 2020, with follow-up for up to 6 years. SDI, EREFS and EoEHSS scores were recorded at ID, at RI, and in RM. Evaluation employed descriptive statistics, the Friedman test, and Bonferroni-corrected post hoc pairwise comparisons. Results At RI 29 and at RM 19 EoE patients provided data. Significant correlations were found between EREFS and EoEHSS at RI and in RM. Pairwise comparisons showed significant differences between ID and RI for SDI, for EREFS, and for EoEHSS. Conclusion The scoring systems tested did not show intercorrelation at ID. Comparison revealed significant differences for SDI, EREFS, and EoEHSS between the systems at ID und RI, but not in RM, during tCS treatment. These results underline the efficacy of tCS (at RI and RM) in the treatment of active EoE. Georg Thieme Verlag KG 2022-11-23 /pmc/articles/PMC9731786/ /pubmed/36417921 http://dx.doi.org/10.1055/a-1855-1974 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Lorenz, Nikolas Johannes
Link, Alexander
Czapiewski, Piotr
Arnim, Ulrike von
Eosinophilic esophagitis: Comparison of clinical, endoscopic and histological scoring systems
title Eosinophilic esophagitis: Comparison of clinical, endoscopic and histological scoring systems
title_full Eosinophilic esophagitis: Comparison of clinical, endoscopic and histological scoring systems
title_fullStr Eosinophilic esophagitis: Comparison of clinical, endoscopic and histological scoring systems
title_full_unstemmed Eosinophilic esophagitis: Comparison of clinical, endoscopic and histological scoring systems
title_short Eosinophilic esophagitis: Comparison of clinical, endoscopic and histological scoring systems
title_sort eosinophilic esophagitis: comparison of clinical, endoscopic and histological scoring systems
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731786/
https://www.ncbi.nlm.nih.gov/pubmed/36417921
http://dx.doi.org/10.1055/a-1855-1974
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