Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension

DNA methylation potentially contributes to the pathogenesis of pulmonary hypertension (PH). However, the role of DNA methyltransferases (DNMTs: 1, 3a, and 3b), the epigenetic writers, in modulating DNA methylation observed in PH remains elusive. Our objective was to determine DNMT activity and expre...

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Detalles Bibliográficos
Autores principales: Jacob, Christina, Kitagawa, Atsushi, Signoretti, Christina, Dzieciatkowska, Monika, D’Alessandro, Angelo, Gupte, Aaditya, Hossain, Shakib, D’Addario, Catherine A., Gupte, Rakhee, Gupte, Sachin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731845/
https://www.ncbi.nlm.nih.gov/pubmed/36372233
http://dx.doi.org/10.1016/j.jbc.2022.102691

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