Identification of galectin-1 and other cellular targets of alpha,beta-unsaturated carbonyl compounds, including dimethylfumarate, by use of click-chemistry probes

α,β-Unsaturated carbonyls are a common motif in environmental toxins (e.g. acrolein) as well as therapeutic drugs, including dimethylfumarate (DMFU) and monomethylfumarate (MMFU), which are used to treat multiple sclerosis and psoriasis. These compounds form adducts with protein Cys residues as well...

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Detalles Bibliográficos
Autores principales: Sauerland, Max B., Helm, Christina, Lorentzen, Lasse G., Manandhar, Asmita, Ulven, Trond, Gamon, Luke F., Davies, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731849/
https://www.ncbi.nlm.nih.gov/pubmed/36493513
http://dx.doi.org/10.1016/j.redox.2022.102560

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