Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction

Human NAD-dependent isocitrate dehydrogenase or IDH3 (HsIDH3) catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the tricarboxylic acid cycle. It consists of three types of subunits (α, β, and γ) and exists and functions as the (αβαγ)(2) heterooctamer. HsIDH3 is regulated allosteric...

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Detalles Bibliográficos
Autores principales: Chen, Xingchen, Sun, Pengkai, Liu, Yan, Shen, Senlin, Ma, Tengfei, Ding, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731866/
https://www.ncbi.nlm.nih.gov/pubmed/36375638
http://dx.doi.org/10.1016/j.jbc.2022.102695

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