Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease

BACKGROUND AND AIMS: Caloric excess and sedentary lifestyles have led to an epidemic of obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of this study was to investigate the mechanisms underlying high fat diet (HFD)-induced NAFLD, and to explore NRF2 activati...

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Detalles Bibliográficos
Autores principales: Liu, Pengfei, Anandhan, Annadurai, Chen, Jinjing, Shakya, Aryatara, Dodson, Matthew, Ooi, Aikseng, Chapman, Eli, White, Eileen, Garcia, Joe GN., Zhang, Donna D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731892/
https://www.ncbi.nlm.nih.gov/pubmed/36495698
http://dx.doi.org/10.1016/j.redox.2022.102570

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