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MicroRNA29B induces fetal hemoglobin via inhibition of the HBG repressor protein MYB in vitro and in humanized sickle cell mice

INTRODUCTION: Therapeutic strategies aimed at reactivating HBG gene transcription and fetal hemoglobin (HbF) synthesis remain the most effective strategy to ameliorate the clinical symptoms of sickle cell disease (SCD). We previously identified microRNA29B (MIR29B) as a novel HbF inducer via targeti...

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Detalles Bibliográficos
Autores principales:	Gu, Qingqing, Palani, Chithra D., Smith, Alana, Li, Biaori, Amos-Abanyie, Ernestine Kubi, Ogu, Ugochi, Lu, Lu, Pace, Betty S., Starlard-Davenport, Athena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732025/ https://www.ncbi.nlm.nih.gov/pubmed/36507536 http://dx.doi.org/10.3389/fmed.2022.1043686

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