Desmoplastic small round cell tumor cancer stem cell-like cells resist chemotherapy but remain dependent on the EWSR1-WT1 oncoprotein

Desmoplastic Small Round Cell Tumor (DSRCT) is a rare and aggressive pediatric cancer driven by the EWSR1-WT1 fusion oncogene. Combinations of chemotherapy, radiation and surgery are not curative, and the 5-years survival rate is less than 25%. One potential explanation for refractoriness is the exi...

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Detalles Bibliográficos
Autores principales: Magrath, Justin W., Kang, Hong-Jun, Hartono, Alifiani, Espinosa-Cotton, Madelyn, Somwar, Romel, Ladanyi, Marc, Cheung, Nai-Kong V., Lee, Sean B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732033/
https://www.ncbi.nlm.nih.gov/pubmed/36506091
http://dx.doi.org/10.3389/fcell.2022.1048709

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