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Inhibition of the Phosphatidylinositol-3 Kinase Pathway Using Bimiralisib in Loss-of-Function NOTCH1-Mutant Head and Neck Cancer

BACKGROUND: PI3K/mTOR inhibition leads to apoptosis of NOTCH1-mutant head and neck squamous cell carcinoma (HNSCC) cells. We tested the efficacy of the PI3K/mTOR inhibitor bimiralisib in patients with NOTCH1-mutant HNSCC. METHODS: Patients with recurrent/metastatic NOTCH1-mutant HNSCC who had progre...

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Detalles Bibliográficos
Autores principales:	Johnson, Faye M, Janku, Filip, Gouda, Mohamed A, Tran, Hai T, Kawedia, Jitesh D, Schmitz, Debora, Streefkerk, Hendrik, Lee, J Jack, Andersen, Clark R, Deng, Defeng, Rawal, Seema, Shah, Pooja A, El-Naggar, Adel K, Johnson, Jason M, Frederick, Mitchell J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Clinical Trial Results
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732253/ https://www.ncbi.nlm.nih.gov/pubmed/36124629 http://dx.doi.org/10.1093/oncolo/oyac185

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