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Experimental and probabilistic model validation of ultrasonic MEMS transceiver for blood glucose sensing

In contrast to traditional laboratory glucose monitoring, recent developments have focused on blood glucose self-monitoring and providing patients with a self-monitoring device. This paper proposes a system based on ultrasound principles for quantifying glucose levels in blood by conducting an in-vi...

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Autores principales: Tripathy, Hara Prasada, Pattanaik, Priyabrata, Mishra, Dilip Kumar, Kamilla, Sushanta Kumar, Holderbaum, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732296/
https://www.ncbi.nlm.nih.gov/pubmed/36481774
http://dx.doi.org/10.1038/s41598-022-25717-x
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author Tripathy, Hara Prasada
Pattanaik, Priyabrata
Mishra, Dilip Kumar
Kamilla, Sushanta Kumar
Holderbaum, William
author_facet Tripathy, Hara Prasada
Pattanaik, Priyabrata
Mishra, Dilip Kumar
Kamilla, Sushanta Kumar
Holderbaum, William
author_sort Tripathy, Hara Prasada
collection PubMed
description In contrast to traditional laboratory glucose monitoring, recent developments have focused on blood glucose self-monitoring and providing patients with a self-monitoring device. This paper proposes a system based on ultrasound principles for quantifying glucose levels in blood by conducting an in-vitro experiment with goat blood before human blood. The ultrasonic transceiver is powered by a frequency generator that operates at 40 kHz and 1.6 V, and variations in glucose level affect the ultrasonic transceiver readings. The RVM probabilistic model is used to determine the variation in glucose levels in a blood sample. Blood glucose levels are measured simultaneously using a commercial glucose metre for confirmation. The experimental data values proposed are highly correlated with commercial glucose metre readings. The proposed ultrasonic MEMS-based blood glucometer measures a glucose level of [Formula: see text] mg/dl. In the near future, the miniature version of the experimental model may be useful to human society.
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spelling pubmed-97322962022-12-10 Experimental and probabilistic model validation of ultrasonic MEMS transceiver for blood glucose sensing Tripathy, Hara Prasada Pattanaik, Priyabrata Mishra, Dilip Kumar Kamilla, Sushanta Kumar Holderbaum, William Sci Rep Article In contrast to traditional laboratory glucose monitoring, recent developments have focused on blood glucose self-monitoring and providing patients with a self-monitoring device. This paper proposes a system based on ultrasound principles for quantifying glucose levels in blood by conducting an in-vitro experiment with goat blood before human blood. The ultrasonic transceiver is powered by a frequency generator that operates at 40 kHz and 1.6 V, and variations in glucose level affect the ultrasonic transceiver readings. The RVM probabilistic model is used to determine the variation in glucose levels in a blood sample. Blood glucose levels are measured simultaneously using a commercial glucose metre for confirmation. The experimental data values proposed are highly correlated with commercial glucose metre readings. The proposed ultrasonic MEMS-based blood glucometer measures a glucose level of [Formula: see text] mg/dl. In the near future, the miniature version of the experimental model may be useful to human society. Nature Publishing Group UK 2022-12-08 /pmc/articles/PMC9732296/ /pubmed/36481774 http://dx.doi.org/10.1038/s41598-022-25717-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Tripathy, Hara Prasada
Pattanaik, Priyabrata
Mishra, Dilip Kumar
Kamilla, Sushanta Kumar
Holderbaum, William
Experimental and probabilistic model validation of ultrasonic MEMS transceiver for blood glucose sensing
title Experimental and probabilistic model validation of ultrasonic MEMS transceiver for blood glucose sensing
title_full Experimental and probabilistic model validation of ultrasonic MEMS transceiver for blood glucose sensing
title_fullStr Experimental and probabilistic model validation of ultrasonic MEMS transceiver for blood glucose sensing
title_full_unstemmed Experimental and probabilistic model validation of ultrasonic MEMS transceiver for blood glucose sensing
title_short Experimental and probabilistic model validation of ultrasonic MEMS transceiver for blood glucose sensing
title_sort experimental and probabilistic model validation of ultrasonic mems transceiver for blood glucose sensing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732296/
https://www.ncbi.nlm.nih.gov/pubmed/36481774
http://dx.doi.org/10.1038/s41598-022-25717-x
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