Impairment of FOXM1 expression in mesenchymal cells from patients with myeloid neoplasms, de novo and therapy-related, may compromise their ability to support hematopoiesis

Bone marrow mesenchymal stem cells (BM-MSCs) exhibit multiple abnormalities in myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML), including reduced proliferative and clonogenic capacity, altered morphology, impaired immunoregulatory properties and capacity to support hematopoiesis. H...

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Detalles Bibliográficos
Autores principales: Falconi, Giulia, Galossi, Elisa, Fabiani, Emiliano, Pieraccioli, Marco, Travaglini, Serena, Hajrullaj, Hajro, Cerretti, Raffaella, Palmieri, Raffaele, Latagliata, Roberto, Maurillo, Luca, Voso, Maria Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732345/
https://www.ncbi.nlm.nih.gov/pubmed/36481766
http://dx.doi.org/10.1038/s41598-022-24644-1

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