Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point

The tight junction protein claudin 6 (CLDN6) is differentially expressed on cancer cells with almost no expression in healthy tissue. However, achieving therapeutic MAb specificity for this 4 transmembrane protein is challenging because it is nearly identical to the widely expressed CLDN9, with only...

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Detalles Bibliográficos
Autores principales: Screnci, Brad, Stafford, Lewis J., Barnes, Trevor, Shema, Kristen, Gilman, Samantha, Wright, Rebecca, Al Absi, Suzie, Phillips, Tim, Azuelos, Charles, Slovik, Katherine, Murphy, Paige, Harmon, Daniel B., Charpentier, Tom, Doranz, Benjamin J., Rucker, Joseph B., Chambers, Ross
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732412/
https://www.ncbi.nlm.nih.gov/pubmed/36505931
http://dx.doi.org/10.1016/j.isci.2022.105665

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