PCW-A1001, AI-assisted de novo design approach to design a selective inhibitor for FLT-3(D835Y) in acute myeloid leukemia

Treating acute myeloid leukemia (AML) by targeting FMS-like tyrosine kinase 3 (FLT-3) is considered an effective treatment strategy. By using AI-assisted hit optimization, we discovered a novel and highly selective compound with desired drug-like properties with which to target the FLT-3 (D835Y) mut...

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Detalles Bibliográficos
Autores principales: Jang, Seong Hun, Sivakumar, Dakshinamurthy, Mudedla, Sathish Kumar, Choi, Jaehan, Lee, Sungmin, Jeon, Minjun, Bvs, Suneel Kumar, Hwang, Jinha, Kang, Minsung, Shin, Eun Gyeong, Lee, Kyu Myung, Jung, Kwan-Young, Kim, Jae-Sung, Wu, Sangwook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732455/
https://www.ncbi.nlm.nih.gov/pubmed/36504722
http://dx.doi.org/10.3389/fmolb.2022.1072028

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