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Identification of an immunogenic epitope and protective antibody against the furin cleavage site of SARS-CoV-2

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the global coronavirus disease 2019 (COVID-19) pandemic, contains a unique, four amino acid (aa) “PRRA” insertion in the spike (S) protein that creates a transmembrane protease serine 2 (TMPRSS2)/furin c...

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Detalles Bibliográficos
Autores principales: Li, Lili, Gao, Meiling, Li, Jie, Xie, Xuping, Zhao, Hui, Wang, Yanan, Xu, Xin, Zu, Shulong, Chen, Chunfeng, Wan, Dingyi, Duan, Jing, Wang, Jingfeng, Aliyari, Saba R., Gold, Sarah, Zhang, Jicai, Qin, Cheng-Feng, Shi, Pei-Yong, Yang, Heng, Cheng, Genhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732504/
https://www.ncbi.nlm.nih.gov/pubmed/36508877
http://dx.doi.org/10.1016/j.ebiom.2022.104401