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Prevalence of ground glass nodules in preschool children: a cross-sectional study

BACKGROUND: Following increased screening efforts and the use of thin-slice computed tomography (CT), there has been a considerable increase in the incidence of ground-glass nodules (GGNs) in adults. As a result, we have more and more treatments for ground-glass nodules in adults, but few in childre...

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Autores principales: Zhang, Lichen, Ma, Xiaohui, Wu, Zhigang, Liu, Jiacong, Gu, Chen, Zhu, Ziyue, Wang, Jiachuan, Shu, Wenbo, Li, Kai, Hu, Jian, Lv, Xiayi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732604/
https://www.ncbi.nlm.nih.gov/pubmed/36506779
http://dx.doi.org/10.21037/tp-22-465
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author Zhang, Lichen
Ma, Xiaohui
Wu, Zhigang
Liu, Jiacong
Gu, Chen
Zhu, Ziyue
Wang, Jiachuan
Shu, Wenbo
Li, Kai
Hu, Jian
Lv, Xiayi
author_facet Zhang, Lichen
Ma, Xiaohui
Wu, Zhigang
Liu, Jiacong
Gu, Chen
Zhu, Ziyue
Wang, Jiachuan
Shu, Wenbo
Li, Kai
Hu, Jian
Lv, Xiayi
author_sort Zhang, Lichen
collection PubMed
description BACKGROUND: Following increased screening efforts and the use of thin-slice computed tomography (CT), there has been a considerable increase in the incidence of ground-glass nodules (GGNs) in adults. As a result, we have more and more treatments for ground-glass nodules in adults, but few in children. Most think development pattern of pulmonary GGNs is lung inflammation, tumor, or tuberculosis that are more related to acquired or environmental factors. By studying the incidence of pulmonary GGNs in preschool children, we sought to determine whether we had ground glass nodules in the lung before we were teenagers, but we didn’t pay attention to them until later. If the hypothesis holds, we may change the cognition and treatment strategies of ground glass nodules. Even not, there are few epidemiological studies with big data that can fill this gap. METHODS: We retrospectively collected the data of all preschool children who had undergone CT at the Children’s Hospital of Zhejiang University School of Medicine from 2013 to 2020. These data were filtered according to the following exclusion criteria: severe artifacts, data with identical names to the original data; and patients without follow-up records (≥3 months). Inclusion criteria: must have undergone thin-slice CT (≤1.25 mm) at the first and last follow-up. Two thoracic radiologists with 5 years of experience and another senior one assessed the images. RESULTS: There were a total of 13,361 cases after relevant exclusions, 311 patients were finally enrolled. Clinical features: age at diagnosis (year): 3.56±1.84, female: 147, male: 164, follow-up interval (month): 6.90±4.74, leukemia: 99, pneumonia: 21, lung cyst: 8, space-occupying lesions outside the lungs: 69, foreign body in respiratory tract: 6. After manual screening and reading, only 1 patient meets all requirements. The results showed that between 2013 and 2020, the incidence of GGNs that could be basically determined in the Children’s Hospital of Zhejiang University School of Medicine was 0.32%. CONCLUSIONS: There have been few previous studies of GGNs in children, and based on our study, we found that there is still some associated morbidity for preschool children, it is rarely found when they are young.
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spelling pubmed-97326042022-12-10 Prevalence of ground glass nodules in preschool children: a cross-sectional study Zhang, Lichen Ma, Xiaohui Wu, Zhigang Liu, Jiacong Gu, Chen Zhu, Ziyue Wang, Jiachuan Shu, Wenbo Li, Kai Hu, Jian Lv, Xiayi Transl Pediatr Original Article BACKGROUND: Following increased screening efforts and the use of thin-slice computed tomography (CT), there has been a considerable increase in the incidence of ground-glass nodules (GGNs) in adults. As a result, we have more and more treatments for ground-glass nodules in adults, but few in children. Most think development pattern of pulmonary GGNs is lung inflammation, tumor, or tuberculosis that are more related to acquired or environmental factors. By studying the incidence of pulmonary GGNs in preschool children, we sought to determine whether we had ground glass nodules in the lung before we were teenagers, but we didn’t pay attention to them until later. If the hypothesis holds, we may change the cognition and treatment strategies of ground glass nodules. Even not, there are few epidemiological studies with big data that can fill this gap. METHODS: We retrospectively collected the data of all preschool children who had undergone CT at the Children’s Hospital of Zhejiang University School of Medicine from 2013 to 2020. These data were filtered according to the following exclusion criteria: severe artifacts, data with identical names to the original data; and patients without follow-up records (≥3 months). Inclusion criteria: must have undergone thin-slice CT (≤1.25 mm) at the first and last follow-up. Two thoracic radiologists with 5 years of experience and another senior one assessed the images. RESULTS: There were a total of 13,361 cases after relevant exclusions, 311 patients were finally enrolled. Clinical features: age at diagnosis (year): 3.56±1.84, female: 147, male: 164, follow-up interval (month): 6.90±4.74, leukemia: 99, pneumonia: 21, lung cyst: 8, space-occupying lesions outside the lungs: 69, foreign body in respiratory tract: 6. After manual screening and reading, only 1 patient meets all requirements. The results showed that between 2013 and 2020, the incidence of GGNs that could be basically determined in the Children’s Hospital of Zhejiang University School of Medicine was 0.32%. CONCLUSIONS: There have been few previous studies of GGNs in children, and based on our study, we found that there is still some associated morbidity for preschool children, it is rarely found when they are young. AME Publishing Company 2022-11 /pmc/articles/PMC9732604/ /pubmed/36506779 http://dx.doi.org/10.21037/tp-22-465 Text en 2022 Translational Pediatrics. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Zhang, Lichen
Ma, Xiaohui
Wu, Zhigang
Liu, Jiacong
Gu, Chen
Zhu, Ziyue
Wang, Jiachuan
Shu, Wenbo
Li, Kai
Hu, Jian
Lv, Xiayi
Prevalence of ground glass nodules in preschool children: a cross-sectional study
title Prevalence of ground glass nodules in preschool children: a cross-sectional study
title_full Prevalence of ground glass nodules in preschool children: a cross-sectional study
title_fullStr Prevalence of ground glass nodules in preschool children: a cross-sectional study
title_full_unstemmed Prevalence of ground glass nodules in preschool children: a cross-sectional study
title_short Prevalence of ground glass nodules in preschool children: a cross-sectional study
title_sort prevalence of ground glass nodules in preschool children: a cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732604/
https://www.ncbi.nlm.nih.gov/pubmed/36506779
http://dx.doi.org/10.21037/tp-22-465
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